alexa STRING V9.1: Edges And Nodes Provide Global Functional Association To Protein Crosstalk And Integration In Urinary Proteomes Of Prostate Cancer | 77879
ISSN: 0974-276X

Journal of Proteomics & Bioinformatics
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Joint Event on 9th International Conference and Expo on Proteomics and Molecular Medicine & 9th International Conference on Bioinformatics

Leonora V Autus-Geniston
United Bayanihan Foundation, Philippines St. Paul University-Quezon City, Philippines
ScientificTracks Abstracts: J Proteomics Bioinform
DOI: 10.4172/0974-276X-C1-106
Abstract
Prostate cancer was the number one cause of cancer in men in Asia. Urine like blood has a similar source of proteins making it an ideal matrix for the study. The research aims to identify proteins in the urinary proteomes of normal controls, benign prostate hyperplasia (BPH) and prostate cancer by initial separation using SDS-PAGE followed by nanoLC-Orbitrap MS/MS aided by ProteinProspector and XCalibur. STRING v9.1 predicted their functional protein association networks among the gene lists. Three hub proteins (B2M, GSN, IGHG1) and FN1 were seen in normal state and BPH, respectively. Six functional modules in normal controls and BPH were seen and 12 in prostate cancer. Five and 15 unique proteins were seen in normal and BPH. HBA1, HBB and TTR were the distinct proteins observed in prostate cancer. A unique BPH module emerged from the normal state when their networks were overlapped. The modules at the center of the prostate cancer networks were tight and multiply connected with looselyarranged periphery. The protein markers of prostate cancer, HBA1-HBB edge in module 1 in the periphery, while TTR in module 6 at the center was connected by haptoglobin (HP) from module 5. Prostate carcinopathogenesis from the normal state involved three protein switches: GSN-FN1, B2M-IGHG1 and CTSB-CSTB edges independent from BPH pathogenesis. From these switches, the expression of the known cancer functional modules emerged that linked further to HBA1-HBB-TTR hub. The details of these events will be discussed. Thus, the present study provides a solid framework for further understanding of prostate pathocarcinogenesis.
Biography

Leonora V Autus-Geniston has completed her PhD from University of Santo Tomas. She is the Officer of United Bayanihan Foundation and an Assistant Professor at Saint Paul University–Quezon City, Philippines. She has published several papers in reputed journals on proteomics and pharmacogenomics, specifically on SNPs on drug metabolizing enzymes among Filipinos. She received the Best Poster Award in Health Science from National Academy of Science and Technology (Philippines) on “Method Development of nanoLC-MS/MS for Identification of Protein Biomarkers in the Urinary Proteomes of Prostate Cancer” and Best Poster in Penang, Malaysia on “Protective Effects of Thiamin on Genotoxicity in Mice”.

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

bornova escort

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7