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The interleukin-7 (IL-7) signaling pathway is paramount in the development and homeostasis of B- and T-cells in the immune
system. Under- and over-stimulation of the IL-7 signaling pathway has been implicated in the pathogenesis of a form
of severe combined immunodeficiency, autoimmune conditions, and several cancers. The interleukin-7 pathway is activated
upon the association of IL-7 with two cellular receptors: IL-7R (CD127) and the shared common gamma-chain (CD132). The
shared common gamma-chain is the activating receptor for IL-2, -4, -7, -9, -15, and -21. We have determined the structures of
IL-7 to glycoforms of the IL-7R extracellular domain and also the unliganded IL-7R. We will present structural and functional
mechanisms of how the IL-7 signaling pathway differs from the common gamma-chain family members. This research is
supported by grant AI72142 from the National Institutes of Health.
Scott Walsh completed his Ph.D. under the guidance of Dr. William DeGrado at the University of Pennsylvania and pursued postdoctoral studies
under the guidance of Dr. Anthony Kossiakoff at the University of Chicago. From 2003 to 2008, he was a professor at the Ohio State University
School of Medicine. From 2008 to the present, he is a professor at the University of Maryland.
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