alexa Structural Bioinformatics Of Proteins Combined With Computational Protein Biophysics: Implications For Nanotechnology Exemplified By G Protein-coupled Receptors
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

4th International Conference on Nanotek & Expo
December 01-03, 2014 DoubleTree by Hilton Hotel San Francisco Airport, USA

Victor Sivozhelezov
Pre Conf: J Nanomed Nanotechnol
DOI: 10.4172/2157-7439.S1.020
Abstract
It has long become evident that bioinformatics of genes and proteins, and biophysical understanding of the mechanisms underlying biomolecular function are very incomplete without one another. Thus, our previous studies have shown that significant insights could be gained in interpreting DNA microarray data within non-statistical, physical criteria-based approaches. More, the ?leader gene? approach based on analysis of protein and gene interactions, developed in Prof. Nicolini?s team, allowed to identifying key genes involved in the given biological process, adding further insights into microarray data. On the other hand, our biophysical studies on the role of electrostatics in protein functioning showed that bioinformatics extension of the results, via homologous proteins, was strongly beneficial for understanding protein functioning, especially for its nanotechnological optimization. This report focuses on G Protein-Coupled Receptors (GPCR), especially the most common drug targets like adrenoreceptors and also light-sensitive proteins with enormous nanotechnology potential like octopus rhodopsin. For such proteins, the key property is their dynamics, especially the parts of the protein conformational space available to them, and how that available space is affected by drug binding or a quantum of light. We describe the combined use of molecular dynamics and structural bioinformatics analysis in exploration of the GPCR conformational space, and show insights into their function and its further optimization. Such insights are unavailable without the combination of biophysics and bioinformatics that could be properly termed ?physical bioinformatics?.
Biography
Victor Sivozhelezov, PhD, is a Leading Scientist, Institute of Cell Biophysics and Russian Academy of Sciences. After obtaining a MS in Chemistry in 1985 at Department of Chemistry, Moscow State University, he joined the same Scientific Computational Center as a Research Associate, and since then was holding tenure positions with the Russian Academy of Sciences, as Junior Researcher (1987), Researcher (1992), Senior Researcher (1998), and Leading Researcher (2008 until now). He was also improving his qualification both as a researcher and in the English language. Since 1994 until now, he was systematically holding Postdoctoral fellowships and doubly-affiliated Visiting Scientist positions at Chair of Biophysics, later Biophysics and Nanobiotechnologies Laboratories, University of Genoa, Italy and Fondazione EL.B.A. ? Nicolini, Pradalunga Bergamo, Italy. His research interests range from molecular recognition, and structure/function relations of proteins and DNA to bioinformatics.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version