alexa
Reach Us +1-217-403-9671
Structure Function Analysis Of Methionine Aminopeptidases And Species Specific Inhibitor Discovery | 9025
ISSN: 0974-276X

Journal of Proteomics & Bioinformatics
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Structure function analysis of Methionine aminopeptidases and species specific inhibitor discovery

3rd International Conference on Proteomics & Bioinformatics

Anthony Addlagatta

AcceptedAbstracts: J Proteomics Bioinform

DOI: 10.4172/0974-276X.S1.069

Abstract
In nature almost all proteins from bacteria to humans, are synthesized with methionine as the starting amino acid coded by AUG. However, about 60-70 % of all the matured proteins lack this initiator methionine. Between the protein synthesis and the maturation processes, this amino acid is removed by the enzyme, methionine aminopeptidases (MetAP). Any alteration in this process is detrimental to the living cell. Based on this observation, MetAPs are regarded as good drug targets. However, the challenge in design of inhibitors specific against species based enzyme is high structural and sequence similarity in the active site. Surprisingly, only one amino acid (a cysteine) is conserved in the S1 pocket where the substrate methionine side chain binds. Using the structural biology, bioinformatics, molecular biology, biochemistry and proteomics approach, we have determined the role of this single amino acid in the substrate recognition for this class of enzymes. Further, we have developed species specific inhibitors. Results from this multi-tool approach to understand the protein function and design of specific inhibitors will be elaborated in the meeting.
Biography
Anthony Addlagatta obtained his bachelor?s degree with specialization in industrial chemistry from Osmania University, Hyderabad, Masters and the Ph.D. degrees in Chemistry from the School of Chemistry, University of Hyderabad. He worked as a Senior Scientist at the Pacific Northwest National Laboratory, USA before joining Indian Institute of Chemical Technology (IICT) in the Centre for Chemical Biology. His current research focus is on the human health and biotechnology. His technical expertise include bioinformatics, protein engineering, molecular, structural, cellular and computational biology, structure based drug discovery, medicinal chemistry and biotechnology.
Leave Your Message 24x7
Top