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Structure Guided Design Of Inhibitors For SH3 Domain Of P47phox Subunit Of NADPH Oxidase 2 Implicated In Various Human Disorders | 6170
ISSN: 2155-6156

Journal of Diabetes & Metabolism
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Structure guided design of inhibitors for SH3 domain of p47phox subunit of NADPH oxidase 2 implicated in various human disorders

3rd World Congress on Diabetes & Metabolism

Sripriya Puppala, M. Soumya, Reshma Chowdary, P.Susrutha and D.Sriram and P.Yogeeswari

Posters: J Diabetes Metab

DOI: 10.4172/2155-6156.S1.019

NADPH oxidases (NOX) are a family of transmembrane proteins of which there are seven isoforms. NOX2 is found in the phagocytes. They are involved in the production of ROS which kills the pathogens. However, under pathological conditions, NOX becomes overexpressed, which can cause oxidative stress implicated in various disorders like Diabetic Retinopathy, Alzheimer?s disease, and Chronic Granulomatous Disease. NOX2 consists of various subunits which can be classified into membrane bound (cytochrome b558) and cytosolic subunits
Sripriya Puppala completed her Bachelors in pharmacy from R.G.R Siddhanthi College of Pharmacy affiliated to Jawaharlal Nehru Technological University, Hyderabad. Currently she is pursuing her Masters in pharmacy from BITS-Pilani Hyderabad Campus, Jawahar Nagar, Hyderabad.