alexa Studies On Protective Effect Of Nigella Sativa Oil On Cisplatin Induced Nephrotoxicity In Rats
ISSN: 2327-5162

Alternative & Integrative Medicine
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

International Conference and Exhibition on Traditional & Alternative Medicine
December 09-11, 2013 Radisson Blu Plaza Hotel, Hyderabad, India

Zeba Farooqui
Posters: Altern Integ Med
DOI: 10.4172/2327-5162.S1.003
Abstract
Cisplatin (CP) is a chemotherapeutic agent which is effective against wide range of malignant tumours. However, its clinical use is limited by its dose dependant nephrotoxicity. Although a number of strategies have been attempted to prevent CP nephrotoxicity, but were not found suitable for clinical practice. Nigella sativa (NS) seeds/oil have been shown to reduce the progression of various cardiovascular and renal disorders. In view of this, the protective effect of NS oil (NSO) on CP induced nephrotoxic and other deleterious effects were investigated. Rats were divided into four groups, rats in the groups CP+NSO and NSO were administered NSO (2 ml/kg bwt orally), with or without single dose of CP treatment (6 mg/kg bwt i.p.) respectively. Serum/urine parameters, activities of brush border membrane (BBM) enzymes and various oxidative stress parameters were analyzed in rat kidney tissue homgenates and/or brush border membrane vesicles (BBMV). CP nephrotoxicity was recorded by increased serum creatinine and blood urea nitrogen. CP caused a significant decrease in the activities of alkaline phosphatase (ALP), γ -glutamyl transferase (GGTase), leucine aminopeptidase (LAP) in homogenates and BBMV. In contrast, NSO administration alone enhanced the activities of BBM enzymes in homogenates as well as in BBMV, indicating an overall improvement in renal BBM integrity. CP caused oxidant/antioxidant imbalances as reflected by decrease in the activities of SOD, CAT, GSH-Px, GR and TR. CP treatment to NSO administered rats markedly enhanced resistance to CP-elicited deleterious effects. In conclusion, NSO appear to protect CP induced nephrotoxicity by improving antioxidant defense mechanism.
Biography
Zeba Farooqui is pursuing Ph.D. from Department of Biochemistry, A.M.U, Aligarh. She is presently working on ?Protective effect of Nigella sativa oil on cisplatin induced nephrotoxicity in rats?.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords