alexa Study Of Cellular DNA Breakage By Flavonoids And Other Polyphenols In The Presence Of Cu (II)
ISSN: 2327-5162

Alternative & Integrative Medicine
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

International Conference and Exhibition on Traditional & Alternative Medicine
December 09-11, 2013 Radisson Blu Plaza Hotel, Hyderabad, India

Hussain Arif, Nida Rehmani, Mohd. Farhan and S. M. Hadi
Posters: Altern Integ Med
DOI: 10.4172/2327-5162.S1.003
Abstract
Flavonoids belong to the polyphenol family and can be visualized as two benzene rings which are joined together with a short three carbon chain. Free radicals cause cellular and DNA damage in our body and consequently induce age-related diseases such as dementia and cancer. Studies in our laboratory have shown that several of the proposed biological antioxidants like tannic acid and flavonoids are themselves capable of generating oxygen free radicals (pro-oxidants), either alone or in the presence of transition metal ions. Earlier we have proposed that an important anticancer mechanism of plant polyphenols and flavonoids may involve mobilization of endogenous copper ions, possibly chromatin bound copper and the consequent pro- oxidant action. Using a cellular system of lymphocytes isolated from human peripheral blood and comet assay, we have shown that flavonoids and other plant polyphenols are able to mobilize nuclear copper in human lymphocytes leading to degradation of cellular DNA. Further, incubation of lymphocytes with neocuproine (a cell membrane permeable copper chelator) inhibited DNA degradation in intact lymphocytes. Bathocuproine, which is unable to permeate through the cell membrane, did not cause such inhibition. This study has further shown that polyphenols are able to degrade DNA in cell nuclei and that such DNA degradation is inhibited by neocuproine as well as bathocuproine (both of which are able to permeate the nuclear pore complex), suggesting that nuclear copper is mobilized in this reaction. Pre-incubation of lymphocyte nuclei with polyphenols indicates that it is capable of traversing the nuclear membrane.
Biography
Hussain Arif has completed his master?s degree from Department of Biochemistry, AMU, and is now pursuing Ph.D. program under the supervision of Prof. S. M .Hadi (Prof. Emeritus). He has attended and presented posters in many national and international conferences.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version