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The distribution in particle size is a factor for the processing behaviour of a powder during pharmaceutical manufacturing.
There is, however, still a need for reports providing evidence for a correlation between the particle size distribution and the
manufacturability of powders. Large granule porosity in wet processed granules has been related to a large fragmentation during
compaction, resulting in mechanical stronger tablets. A decreased primary particle size increases the tablet strength. However,
this assumption is provided that the particles stay intact during compaction. The interaction between the particles can be complex
and depend on physical properties such as particle size, shape, deformation behavior etc. Powder flow properties deteriorate
nearly exponentially with decreasing particle size. For a powder exhibiting marginal flow properties during powder handling,
granule size enlargement is an effective means to improve flow properties and manufacturability. To obtain constant powder flow
of a given formulation, granule/particle size should be carefully controlled. Hence aim of present work was to study particle size
distribution and flow properties of granules prepared by different granulation techniques which affect final tablet performance.
In this study granules were prepared by different granulation techniques and characterized for its physical properties. Results
showed that, primary particle size had a strong effect on granule growth rate, granule size distribution, granule porosity and also
on hardness of tablet.
Miss. Varsharani B. Khot is post graduate student of Dept. of Pharmaceutics, Tatyasaheb Kore College of Pharmacy, Warananagar affiliated with
Shivaji University Kolhapur.
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