alexa Study Of Proteome Heterogeneity And Dynamics
ISSN: 0974-276X

Journal of Proteomics & Bioinformatics
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

8th International Conference on Proteomics and Bioinformatics
May 22- 24, 2017 Osaka, Japan

Stanislav Naryzhny
Institute of Biomedical Chemistry & Petersburg Nuclear Physics Institute, Russia
Keynote: J Proteomics Bioinform
DOI: 10.4172/0974-276X-C1-096
Abstract
Human proteome is tremendously complex and composed from diverse and heterogeneous gene products (proteoforms). Recent developments in mass spectrometry and systematic approaches (technology and methodology) promise to bring new insights into this complexity. A combination of mass spectrometry with classical biochemical separation technologies is particularly attractive for this systematic investigation. Among biochemical methods, two-dimensional gel electrophoresis (2DE) is a most powerful protein separation technique that allows not just separating proteoforms but determining their physic-chemical parameters (pI and Mw). In our study, we performed the panoramic analysis of cellular proteins using a combination of virtual (in silico) and experimental 2DE with high-resolution nano-liquid chromatography-mass spectrometry. This approach is moving proteomics study on the next level of the acquisition of knowledge about proteomes. To get better impression about diversity of proteoforms in a particular proteome, whole gels (not just spots but sections) were analyzed using this approach. This allowed to detecting in a single proteome more than 20000 proteoforms coded by more than 4000 genes. The 3D-graphs showing distribution of these proteoforms including proteoforms of biomarkers in 2DE map were generated. A comparative analysis of these graphs between normal and cancer cells was performed. This analysis showed a high variability and dynamics of proteoforms.
Biography

Stanislav Naryzhny obtained his PhD from the Biophysics Institute in Pushchino, Russia and did his Postdoctoral Studies from St. Petersburg Nuclear Physics Institute (PNPI), Gatchina, Russia and from the Northeastern Ontario Regional Cancer Centre, Sudbury, Canada. He is the Head of Proteomics Laboratory of Petersburg Nuclear Physics Institute at National Research Center "Kurchatov Institute" and also Chief Scientist at Institute of Biomedical Chemistry, Moscow, Russia. He is a protein Biochemist with extensive hands-on experience in academia with strong background in protein structure-function theory and expertise in processes involved in DNA replication, DNA stability and tumorigenesis; protein, protein structure and proteomics analysis employing a wide variety of biophysical and biochemical methods. His area of research lies in the two-dimensional gel electrophoresis (2DE) based proteomics, where he has published more than 40 papers in reputed journals.

Email: snaryzhny@mail.ru

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords