Reach Us +44-1625-708989
Study Of The Relation Between Serum Testosterone Level And Carotid Atherosclerosis In Elderly Males | 47696
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Study of the relation between serum testosterone level and carotid atherosclerosis in elderly males

8th Global Cardiologists & Echocardiography Annual Meeting

Nany Hassan Abu Al-Makarim El Gayar

Alexandria University, Egypt

ScientificTracks Abstracts: J Clin Exp Cardiolog

DOI: 10.4172/2155-9880.C1.035

Objective: The aim of this work is to evaluate the relationship between serum testosterone concentration and carotid atherosclerosis in elderly males. Methods: The current study included 40 subjects who were classified into two groups; the first group included 30 elderly healthy males as the cases group and the second group included 10 young males as the control group. Serum level of total testosterone was measured using immunoassay kits, sex hormone binding globulin (SHBG) was measured using immunoassay kits and free androgen index (FAI) was calculated. Results: Ultra-sonographic measurement of carotid intima-media thickness (IMT). Total testosterone level was significantly lower in the cases group than control group (t=5.354, p<0.001). SHBG was significantly higher in the cases group than the control group (t=4.796, p<0.001). Free androgen index (FAI) was significantly lower in cases group than control group (z=4.686, p<0.001). Intima-Media thickness (IMT) was significantly higher in the cases group than the control group (t=3.513, p=0.001). As regards the number of plaques 10 males from the cases group did not have any plaques, 13 males had one plaque and 7 males had two plaques however in the control group 9 males did not have any plaques and only one male, had one plaque, so cases group had significantly higher prevalence of plaques than the control group (z=3.007, p=0.003). A significant negative correlation between total testosterone and SHBG (R=-0.856, P<0.001), a significant positive correlation between total testosterone and FAI (R=0.957, P<0.001), and a significant negative correlation between testosterone and both IMT (R=-0.501, P=0.005) and number of plaques and (R=-0.358, P=0.52). SHBG was negatively correlated with FAI (R=-0.845, P<0.001) but it was positively correlated with both IMT (R=0.392, P=0353) and number of plaques (R=0.032, P=0.056). There were significant negative correlations between FAI and both IMT (R=-0.601, P<0.001) and number of plaques (R=-0.461, P=0.010). IMT was positively correlated with the number of plaques (R=0.760, P<0.001). Conclusion: These findings suggest that normal physiologic testosterone levels may help to protect men from the development of atherosclerosis. In elderly men, low plasma testosterone is associated with elevated carotid intima-media thickness. A negative correlation has been demonstrated between endogenous testosterone levels and IMT of the carotid arteries. These findings suggest that men with lower levels of endogenous testosterone may be at a higher risk of developing atherosclerosis.

Nany Hassan Abu Al-Makarim El Gayar is an Assistant Professor of Internal Medicine, Geriatrics Department at Alexandria University, Egypt. He has done MS in Rheumatology and MD in Geriatrics. He has published 10 papers in reputed journals.

Email: [email protected]