alexa Study Of The Relationship Between Anti-citrullinated Protein Antibodies And Occurrence Of Interstitial Lung Disease In Rheumatoid Arthritis Patients
ISSN: 1948-5956

Journal of Cancer Science & Therapy
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16th Global Annual Oncologists Meeting
April 24-25, 2017 Dubai, UAE

Ragaa Abdel Kader Mahmoud, Mona Helmy Abdel Migiud, Mahmoud Ibrahim Mahmoud, Eman Abdel Ghani Sayd and Abeer Ali Ahmed Desouki
Alexandria University, Egypt
Posters & Accepted Abstracts: J Cancer Sci Ther
DOI: 10.4172/1948-5956-C1-097
Abstract
Background: The pulmonary manifestations in RA patients were firstly reported half a century ago and affected 10 to 20% of RA patients, which is associated with increased mortality. The ILD has been recognized as the most common complication in the lung of RA patients and the second cause of death in those patients. Objective: Patients with rheumatoid arthritis (RA) have risk to develop RA associated interstitial lung disease (RA-ILD) and the relation between RA & ILD is to be assessed. This study aimed at investigating the potential association of the positivity of serum anti-citrullinated protein antibody (ACPA) with RA-ILD in RA patients with positive RF titre. Patients & Methods: A total of 40 RA patients were collected between 2015 and 2017 with positive RF titre in there sera & age matched between 30 – 65 years old , who were diagnosed according to Eular/ACR 2010 criteria for diagnosis of rheumatoid arthritis. Individual patients were screened for the evidence of ILD with high resolution CT imaging (HRCT) and pulmonary function test (PFT). The titre of serum ACPA and RF were measured in individual patients from outpatient Rheumatology and Immunology Clinic of Alexandria Police Hospital, Department of Internal Medicine (Rheumatology & Immunology unit), Faculty of Medicine, University of Alexandria, Alexandria, Egypt. Results: There were 11 RA patients with RA-ILD, accounting for 27.5% in this study. The positive rates of ACPA and RF in the patients with RA-ILD were significantly higher than that in the patients with RA-only (45% vs. 10%, p=0.013).
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