alexa Study On Relationship Between Genetic Expression Of BDNF And NRG-1 And Myelinated Nerve Fiber Density And Cross-sectional Area In Thoracic Sympathetic Trunk Of Palmar Hyperhidrosis
ISSN: 2155-9554

Journal of Clinical & Experimental Dermatology Research
Open Access

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4th International Conference on Clinical & Experimental Dermatology
April 14-16, 2014 Hilton San Antonio Airport, TX, USA

Zhan Hua-hui and Tu Yuan-rong
Accepted Abstracts: J Clin Exp Dermatol Res
DOI: 10.4172/2155-9554.S1.015
Abstract
Objective:To investigate the gene expressions of brain-derived neurotrophic factor (BDNF) and neuregulin (NRG-1) in thoracic sympathetic trunk and their relation to myelinated nerve fiber density and single myelinated nerve fibers cross- sectional area in palmar hyperhidrosis. Methods: Fast red - fast green myelin sheath staining was used to show myelinated nerve fibers. Through the micro-image analysis system, 30 cases of myelinated nerve fiber density and single myelinated nerve fibers cross-sectional area were observed in T3 thoracic sympathetic trunk of patients with palmar hyperhidrosis. BDNF and NRG-1 gene expressions were also analyzed by RT-PCR method. 8 cases of non-palmar hyperhidrosis patients were included as control study. Results: In T3 thoracic sympathetic trunk of patients with palmar hyperhidrosis, myelinated nerve fiber density and single myelinated nerve fibers cross-sectional area were significantly higher than that with non-palmar hyperhidrosis (t=7.023, P﹤0.05; t=7.462, P﹤0.05 respectively). The expressions of BDNF and NRG-1 in T3 thoracic sympathetic trunk of patients with palmar hyperhidrosis was 1.1760?0.02870, 1.2161?0.07539 respectively. In control group they were 1.0375?0.05379, 1.0427?0.04357 respectively. The former was significantly higher than the latter(t=9.940, P﹤0.05) t=6.195, P﹤0.05 respectively. Conclusion: BDNF and NRG-1 gene over expression increased myelinated nerve fiber density and single myelinated nerve fibers cross-sectional area of thoracic sympathetic trunk in palmar hyperhidrosis. Thus transmission speed and ability of excitatory of thoracic sympathetic nerve have also increased. It may play a role in the pathogenesis of palmar hyperhidrosis.
Biography
Zhan Hua-hui has completed his M.D. at the age 22 from Fujian Medical University. He is the director of thoracic surgery department in the first hospital of Fuzhou city. He is a board member of thoracic surgery society of Fujian Association of Integrative Medicine. He has published more than 10 papers in reputed journals.
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