alexa Study On The Diagnostic And Prognostic Aspects Of Bone Marrow Microenvironment Components In Non- Hodgkins Lymphoma Before And After Therapy
ISSN: 2157-7013

Journal of Cell Science & Therapy
Open Access

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8th World Congress and Expo on Cell & Stem Cell Research
March 20-22, 2017 Orlando, USA

Amira Hanafi Soliman
Cairo University, Egypt
Posters & Accepted Abstracts: J Cell Sci Ther
DOI: 10.4172/2157-7013.C1.039
Objectives: The main goal of the study is the evaluation of the stromal cells of bone marrow microenvironment (BMM) in bone marrow trephine biopsy (BMTB) and fibronectin, tumor necrosis factor- alpha (TNF-α), L-selectin of bone marrow (BM) plasma in Non-Hodgkin’s Lymphoma (NHL) patients, before and after therapy. Material & Methods: A total of 80 de novo NHL patients which were divided as B-cell lymphoma 64/80 (80%), comprising follicular cell lymphoma (FCL) 32/80 (40%) patients, chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) 12/80 (15%) patients, and diffuse large cell lymphoma 20/80 (25%) patients and T-cell lymphoma, which constituted 16/80 (20%) of patients, all diagnosed as T-Lymphoblastic lymphoma. Patients were evaluated before and after therapy, and compared to 25 BM donors as control group. BMTB and BM aspirate were taken for morphological assessment of stromal cell. Plasma of BM samples was examined for TNFα, L-selectin, which were tested by ELISA technique, and Fibronectin by Radial immunodiffusion (RID). Results: BM stromal cells comprising reticular macrophages and fibroblasts were increased in 53.3% of NHL at diagnosis. BM Fibronectin levels were decreased, while BM TNFα and L-selectin were higher at diagnosis in comparison to CR (p<0.05) and control (p<0.05). In NHL, elevated values of BM TNFα and BM L-selectin were associated with signs of aggressive disease, including, extra nodal sites were increased (>1), detectable B cell-symptoms, high grade NHL, signs of BM and CNS invasion, high International prognostic index (IPI) (p<0.05). Conclusion: BMM components, TNFα, L-selectin and fibronectin in NHL can be useful in evaluating disease activity, extent and response to treatment and as prognostic markers according to (IPI).


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