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Suitability Of Plasticised Polymers For Hot Melt Extrusion Process Ethyl Alcohol As Desolvating Agent | 7416
ISSN: 2167-7689

Pharmaceutical Regulatory Affairs: Open Access
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Suitability of plasticised polymers for hot melt extrusion process ethyl alcohol as desolvating agent

2nd International Conference and Exhibition on Pharmaceutical Regulatory Affairs

Amol M. Sabale

Posters: Pharmaceut Reg Affairs

DOI: 10.4172/2167-7689.S1.007

Polymer for hot melt extrusion must exhibit thermoplastic characteristics in order to permit melt extrusion process and they must be stable at processing temperature. Other important characteristics are: suitable glass transition (Tg) of 50-180oC, low Hygroscopicity and no toxicity since large amount of polymers are used. Extrudability of polymer is mainly determined by glass transition temperature and melt viscosity. Polymers having high molecular weight can hardly be extruded due to their high melt viscosity. Moreover, a high Tg required high processing temperature which can degrade sensitive drug. As a general rule, an extrusion should be run at temperature 20-40oC above the Tg. Most polymers exhibit thixotropic behaviour which means that the viscosity declines as function of increasing shear stress. So the study is designed to determine the influence of several plasticizers on the Tg and melt viscosity of polymer
Amol M. Sabale, doing M.Pharm (Pharmaceutics) in Tatyasaheb Kore College of Pharmacy, Warananagar, Shivaji University, Kolhapur. Qualified GPAT and entrance examination for NIPER in 2011. Presented posters in various national and international conferences.