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Polymer for hot melt extrusion must exhibit thermoplastic characteristics in order to permit melt extrusion process and they
must be stable at processing temperature. Other important characteristics are: suitable glass transition (Tg) of 50-180oC, low
Hygroscopicity and no toxicity since large amount of polymers are used. Extrudability of polymer is mainly determined by glass
transition temperature and melt viscosity. Polymers having high molecular weight can hardly be extruded due to their high melt
viscosity. Moreover, a high Tg required high processing temperature which can degrade sensitive drug. As a general rule, an
extrusion should be run at temperature 20-40oC above the Tg. Most polymers exhibit thixotropic behaviour which means that the
viscosity declines as function of increasing shear stress. So the study is designed to determine the influence of several plasticizers
on the Tg and melt viscosity of polymer
Amol M. Sabale, doing M.Pharm (Pharmaceutics) in Tatyasaheb Kore College of Pharmacy, Warananagar, Shivaji University, Kolhapur. Qualified
GPAT and entrance examination for NIPER in 2011. Presented posters in various national and international conferences.
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