alexa Superiority Of Anti-cancer Drugs Whose Efficacy Increases Under Acidic Conditions | 22673
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

4th World Congress on Cancer Science & Therapy

Hiroshi Kobayashi
ScientificTracks Abstracts: J Cancer Sci Ther
DOI: 10.4172/1948-5956.S1.033
Abstract
Although blood and tissues are usually maintained at pH around 7.4 in mammals, the extracellular pH drops below 6.5 in solid cancer nests. Such acidic environments may decrease intracellular pH and disrupt cellular functions mediated by a large number of enzymes with pH sensitive catalytic activity. Target molecules of anti-cancer drugs are largely enzymes whose activity is dependent on pH, suggesting that the efficacy of anti-cancer drugs varies as pH changes. We have measured the inhibitory effect of over 270 well-known compounds on cancer cell proliferation in media of pH 7.5 and 6.7, and five compounds, lovastatin, cantharidin, manumycin A, doxorubicin, and ionomycin, showed high inhibition at pH 6.7, but their inhibitory effects were low at pH 7.5. We further examined the inhibitory mechanism of statins and found that the inhibition was caused by the decrease in protein geranylgeranylation. Clinical investigations have revealed the therapeutic effect of statins on cancer patients. It can be argued that the anti-cancer drugs with high efficacy under acidic conditions have low side effects on cells in normal tissues, especially immune cells in blood, because normal tissues and blood are generally slightly alkaline. In fact, statins are now prescribed for the treatment of hyperlipidemia with low side effects. These results suggested that the screening of anti-cancer compounds in acidic medium would be useful for development of new anti-cancer chemotherapeutics.
Biography
Hiroshi Kobayashi has completed his PhD (1974) in Biochemistry from University of Tokyo in Japan. After his Postdoctoral training at Colorado University Medical Center in USA, he started to study adaptation strategies of microorganisms to acidic environments at Chiba University in 1978. His recent research is focused on mammalian cell functions under acidic conditions from 1996 at Graduate School of Pharmaceutical Sciences, Chiba University. He retired in March 2012 and continues his research as a Professor Emeritus at Chiba University. He has published more than 20 papers in reputed journals during the recent 10 years.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7