alexa Synthesis And Anticancer Screening Studıes Of Indole-based Piperazıne Derivatives
ISSN: 1948-5956

Journal of Cancer Science & Therapy
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3rd World Congress on Cancer Science & Therapy
October 21-23, 2013 DoubleTree by Hilton Hotel San Francisco Airport, CA, USA

Mine Yarim, Meric Koksal, Irem Durmaz and Rengul Cetin-Atalay
ScientificTracks: J Cancer Sci Ther
DOI: 10.4172/1948-5956.S1.028
Abstract
The preparation of the compounds is illustrated in Scheme 1 . The groups of 3-{[4-(substituted phenyl⁄benzyl)piperazin- 1-yl]methyl}-1H-indole 1a-ca, 1,3-di-{[4-(4-fluorophenyl)piperazin-1-yl]methyl}-1H-indole 2a and 1-{[4-(substituted phenyl ⁄ phenylethyl)piperazin-1-yl]methyl}-3-methyl-1H-indole 3a-b were prepared by Mannich reaction of substituted piperazine and formaldehyde with indole or 3-methylindole. The crude products were purified by recrystallization or column chromatography. 1-{3-[4-(substitutedphenyl)piperazin-1-yl]propyl}-1H-indole 4a-c were synthesized by the reaction of indole and 1-(3-chloropropyl)-4-(substituted phenyl) piperazine in presence of potassium hydroxide. To obtain 1-(3-chloropropyl)-4- (substitutedphenyl) piperazine, substituted phenyl piperazine was reacted with 1-bromo-3-chloropropane. Compounds 4a-c were purified by column chromatography on silica gel using ethyl acetate ⁄n-hexane as a mobile phase system (Scheme 1). Structures of compounds were clarified with IR, 1 H-NMR, 13 C-NMR, mass spectroscopies and elemental analyses.
Biography
Mine Yarim has studied anticancer drug design for 20+ years, during which time she has authored several peer-reviewed reports. She has served on numerous review committees for the National Science Foundation in Turkey.
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