alexa Synthesis And Anticancer Screening Studies Of Benzothiazole-based Piperazine Derivatives
ISSN: 1948-5956

Journal of Cancer Science & Therapy
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4th World Congress on Cancer Science & Therapy
October 20-22, 2014 DoubleTree by Hilton Hotel Chicago-North Shore Conference Center, USA

Mine Yarim, Ece Gurdal, Tugce Deniz Gol, Irem Durmaz and Rengul Cetin-Atalay
ScientificTracks Abstracts: J Cancer Sci Ther
DOI: 10.4172/1948-5956.S1.033
Abstract
This lecture will cover our study on benzothiazole-based piperazine derivatives and their cytotoxic activities. Target compounds were synthesized according to reactions shown below in reaction scheme. Structures of compounds were clarified with IR, 1H-NMR, 13C-NMR, mass spectroscopies and elemental analyses. In vitro cytotoxic activities were screened in comparison with camptothecin (positive control) and 5-fluorouracil (reference) by sulphorhodamine B assay against breast cancer (MCF-7), hepatocellular carcinoma (HUH-7) and colorectal carcinoma (HCT-116) cell lines. The most potent compound against HUH-7 and MCF-7 cell line was compound 1d; IC50 = 3,1 μM and IC50 = 9,2 μM, respectively. The most potent compounds against HCT-116 cell line were compound 1a; IC50 = 4,8 μM and compound 2a; IC50 = 4,5 μM.
Biography
Mine Yarim has studied anticancer drug design and authored several peer-reviewed reports. She has served on numerous review committees for the National Science Foundation in Turkey. She has served on the editorial boards for the Pharmacologia. She is a member of the QSAR Society.
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