alexa Synthesis And Anti-malarial Screening, Of (N1, N1,-diethyl-N4,-dihydroartemisinin-10-yl) Pentane-1, 4-diamine (PdP)
ISSN: 2329-6836

Natural Products Chemistry & Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

2nd International Conference and Exhibition on Pharmacognosy, Phytochemistry & Natural Products
August 25-27, 2014 DoubleTree by Hilton Beijing, China

Ezekiel O Afolabi, Akor Joseph, Azoba Anthony, Quadri O Usman and Arome David
Accepted Abstracts: Nat Prod Chem Res
DOI: 10.4172/2329-6836.S1.005
Abstract
Antimalarias are chemotherapeutic agents used for the prevention and treatment of malaria. Artemisinin and its derivatives has been discovered to be the anti-malarial drug of first choice because it is highly curative, effective on most stages of plasmodium life cycle, safe during the first, second and third trimesters, and safe for all ages. WHO, nevertheless, has recommended artemisinin based combination therapy (ACT) to guard against possible development of resistance like observed with chloroquine. In view of this fact we proposed coupling dihydroartemisinin, a derivative of artemisinin and 2-amino, 5-diethyl amino pentane, the chloroquine handle by using an SN2 reaction mechanism. The Mitsunobu (1967) coupling method, involving diisopropyl azodicarboxylate (DIAD), triphenyl phosphine (Ph3P), 2-amino, 5-diethyl amino pentane and dihydroartemisinin (DHA) at room temperature was adopted to synthesis our target compound, (N1, N1,-diethyl- N4,-dihydroartemisinin-10-yl)pentane-1,4-diamine (PdP) (IUPAC Name: N1,N1-diethyl-N4-(3,6,9-trimethyldecahydro-3,12- epoxy[1,2]dioxepino[4,3-i] isochromen -10-yl) pentane-1,4-diamine). The structure of ?PdP? was confirmed by its mass spectra fragmentation patterns. The compound was screened at three dose levels of 3 mg/Kg, 10 mg/Kg and 30 mg/Kg, for in-vivo curative anti-malaria activity against infected mice with Plasmodium berghei with an LD50 of 330 mg/Kg in mouse by oral route.
Biography
Ezekiel O Afolabi is a Senior Lecturer in the Department of Pharmaceutical Chemistry, University of Jos, Jos, Nigeria. His first degree was in Chemistry, (BSc (Hons.) Chemistry, Ibadan, 1976). After teaching for a while at secondary school level, he was appointed a Graduate Assistant at Ahmadu Bello University, Zaria, in September 1979, where he obtained MSc in Pharmaceutical Chemistry in August 1982. In 1983 and 1993 respectively, he was a visiting research student for nine months to Professor Keith Bowden, University of Essex, Colchester, and Professor Stephen Matlin, University of Warwick, Coventry, both in England (U.K.). In September 2011, he defended his PhD Thesis and has supervised more than 60 undergraduate student projects and has twelve Journal Papers.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version