Synthesis And Biological Evolution Of Pladienolide B Analogues | 7588
Pharmaceutical Regulatory Affairs: Open Access
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Pladienolides A to G, novel 12-membered macrolides were isolated from Streptomyces platensis Mer-11107, with pladienolide
B the most potently inhibiting hypoxia induced-VEGF expression and proliferation of the U251 cancer cell line. A growth
inhibitory study using a 39-cell line drug-screening panel demonstrated that pladienolide B has strong antitumor activities in
vitro. It has a unique antitumor spectrum that sets it apart from anticancer drugs currently in clinical use. Pladienolide B has a
novel mechanism of action. Pladienolide B extensively inhibits tumor growth in xenograft models. In the most sensitive model,
using BSY-1 xenografts, tumors were completely regressed by administration of Pladienolide B. For the reason of their novel
mechanism of action and excellent in vivo efficacy, pladienolides appear to have major potential for use in cancer treatment.
Here in we are reporting the synthetic path way and synthesis of Pladienolide B analogues which are undergoing for biological
evaluation to establish lead molecules.
Scheme: Retrosynthesis of Pladienolide B analogues.
Praveen Kumar. Vemula obtained his Masters in Chemistry in the year 2006 from Osmania University with FIRST rank. He specializes in synthesis of
Natural products and bio-active small molecules. He is a Senior Research Fellow under CSIR and presently he is a researcher in the field of Natural
products synthesis with Indian Institute of Chemical Technology Hyderabad. He has two research articles published in peer reviewed journals and
he has attended six national and international conferences.
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals