alexa Synthesis And Pharmacological Screening Of Some Benzimidazole Derivatives
ISSN: 1948-593X

Journal of Bioanalysis & Biomedicine
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

3rd International Conference and Exhibition on Biowaivers, Biologics & Biosimilars
October 27-29, 2014 Hyderabad International Convention Centre, Hyderabad, India

Sunila T Patil, Sunil P Pawar, Parloop A Bhatt and Md. Rageeb and Md. Usman
Posters: J Bioanal Biomed
DOI: 10.4172/1948-593X.S1.014
The main objective of the medicinal chemistry is to synthesize the compounds that show promising activity as therapeutic agents with lower toxicity. Benzimidazole derivatives are very useful compound with well known biological activity. Notable among these are antibacterial, antiviral, antifungal, analgesic, anti-inflammatory and anticancer. In the current research work, the title compounds 5-ethoxy-2-substituted benzimidazole, were synthesized by nitration of phenacetin with concentrated nitric acid it gives N-(2-nitro-5-ethoxyphenyl) acetamide (I). Compound (I) on reduction with alcohol gives 5-ethoxy-2-nitroaniline (II). Reaction of compound (II) with hydrazine hydrate produced 5-ethoxy ortho phenylene diamine (III). The reaction of compounds (III) with substituted acids yielded the corresponding 5-ethoxy-2-substituted benzimidazole (IV). The identification and characterization of the synthesized compounds were carried out by elemental analysis, melting point, thin layer chromatography, FT-IR, NMR and mass data to ascertain that all synthesized compounds were of different chemical nature than the respective parent compound. The compounds were screened for anti-inflammatory activity. The antiinflammatory activities of compounds were done by using Carrageenan induced rat paw edema method. The test compounds IVa, IVd and VIg showed significant anti-inflammatory activity compared with the standard drug Ibuprofen.
Sunila T Patil has completed MPharm from T.V.E.S?s College of Pharmacy Faizpur, affiliated to North Maharashtra University Jalgaon passed with first class and PhD from Jodhpur National University, Jodhpur. She published 10 international research articles in impact factor journals. She has attended 16 national & international seminar/conferences and has presented 8 papers in various seminars. Also she has acted as co-coordinator for 2 one day workshop.
image PDF   |   image HTML
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version