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Benzimidazoles are compounds of wide range of biological activity. The benzimidazole nucleus in general, is an important
synthetic strategy in drug discovery. Structure activity relationship (SAR) has indicated that there is a relationship between
the inductive effect of the substituent and the biological activity of benzimidazoles. A series of substituted 2-(L-arabinotetritol-
1-yl) benzimidazole analogs with different substituents having electron attracting or electron release properties at
the benzimidazole base moiety was prepared. A correlation between the inductive effect of the substituent and its spectral
properties at the UV and NMR spectra were obtained. Quantitative structure activity relationship (QSAR) of the substituted
benzimidazole analogs was determined. Twelve test bacteria representing three groups of bacteria were used to evaluate the
biological activity of the compounds.
Mohammed A E Sallam is working as Professor of Organic Chemistry Faculty of Science, Alexandria University. He got his PhD from Alexandria University and
several Postdoctoral fellowships. He is a visiting Scientist at Biochemistry Department Purdue University, Medicinal Chemistry, Michigan State University, Medicinal
Chemistry, Ohio State University, Department of Chemistry and University of Trondheim, Norway. He attended 18 meetings around the world and is the Board
editor of several Journals; J. ofCarbohydrate Chemistry, 1983-2000, Green and sustainable Chemistry, GSC, 2011-present, and Vitamins and Minerals Reports,
November 2013-present. His major fields of interests are Carbohydrates and C-nucleosides, heterocyclic, synthesis of polymers with biological activity.
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