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Synthesis And UV Spectral Studies Of Substituted 2-(L-arabino-tetritol-1-yl) Benzimidazole Analogs: Quantitative Structure Activity Relationships (QSAR) | 21221
ISSN: 2161-0401

Organic Chemistry: Current Research
Open Access

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Synthesis and UV spectral studies of substituted 2-(L-arabino-tetritol-1-yl) benzimidazole analogs: Quantitative structure activity relationships (QSAR)

International Summit on Past and Present Research Systems of Green Chemistry

Mohammed A E Sallam, Omnia G Abdel Hamid, Sergio Abbate and France Lebon

Accepted Abstracts: Organic Chem Curr Res

DOI: 10.4172/2161-0401.S1.005

Benzimidazoles are compounds of wide range of biological activity. The benzimidazole nucleus in general, is an important synthetic strategy in drug discovery. Structure activity relationship (SAR) has indicated that there is a relationship between the inductive effect of the substituent and the biological activity of benzimidazoles. A series of substituted 2-(L-arabinotetritol- 1-yl) benzimidazole analogs with different substituents having electron attracting or electron release properties at the benzimidazole base moiety was prepared. A correlation between the inductive effect of the substituent and its spectral properties at the UV and NMR spectra were obtained. Quantitative structure activity relationship (QSAR) of the substituted benzimidazole analogs was determined. Twelve test bacteria representing three groups of bacteria were used to evaluate the biological activity of the compounds.
Mohammed A E Sallam is working as Professor of Organic Chemistry Faculty of Science, Alexandria University. He got his PhD from Alexandria University and several Postdoctoral fellowships. He is a visiting Scientist at Biochemistry Department Purdue University, Medicinal Chemistry, Michigan State University, Medicinal Chemistry, Ohio State University, Department of Chemistry and University of Trondheim, Norway. He attended 18 meetings around the world and is the Board editor of several Journals; J. ofCarbohydrate Chemistry, 1983-2000, Green and sustainable Chemistry, GSC, 2011-present, and Vitamins and Minerals Reports, November 2013-present. His major fields of interests are Carbohydrates and C-nucleosides, heterocyclic, synthesis of polymers with biological activity.