Synthesis of 2-substituted pyrazolines as potential antimalarial and antimicrobial agents

10^th World Congress on Medicinal Chemistry and Drug Design

June 14-15, 2018 | Barcelona, Spain

Nitendra K Sahu

SRK University, India

Posters & Accepted Abstracts: Med chem (Los Angeles)

Abstract :

A novel series of 2-substituted pyrazolines were synthesized and evaluated for in vitro antimalarial efficacy against chloroquine sensitive (MRC-2) as well as chloroquine resistant (RKL9) strains of Plasmodium falciparum. Compounds were confirmed by elemental analyses, IR, 1H NMR and 13C NMR spectral data. Compounds 5o (IC50=0.032 �¼M for MRC-2 and IC50=0.209 �¼M for RKL-9) displayed better antiplasmodial activity than chloroquine. The antibacterial and antifungal evaluations were also conducted, compounds 5d and 5k exhibited better antibacterial activity against S. aureus, B. subtilis, E. coli and P. aeruginosa than ciprofloxacin. Antifungal activity of compound 5n against A. niger (MIC-3.36 �¼g/ml) and C. albicans (MIC-6.9 �¼g/ml) was found to be better than the standard drug fluconazole.