Synthesis of Benzopyrano[4,3-d]-Pyrimidine derivatives and some of their antimicrobial and cytotoxicity activities
5th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems
March 16-18, 2015 Crowne Plaza, Dubai, UAE

Haya A Abubshaita and Hassn K Ibrahimb

Posters & Accepted Abstracts: Pharm Anal Acta

Abstract:

Benzopyrano-pyrimidine derivatives (3a-c and 4) were prepared viacyclocondensation of 3-ethoxycarbonyl coumarin derivatives (2a-c) with guanidine hydrochloride and thiourea under reflux. Acetylation of (3b, c) with acetic anhydride provided N-acetyl derivatives (5a, b) - imidazolo-[2,1-a]-benzopyrano [4, 3-d]-pyrimidin-1, 6-dione (6) was obtained by treatment of 2-amino-benzopyrano[4,3-d]-pyrimidine with ethylchloroacetate. Structures of these compounds were established on basis of IR, 1H-NMR and MS data. Some of the prepared compounds were evaluated for antimicrobial and antitumor activties.