alexa Synthesis Of Poly(L-lysine)-based Star Polypeptides As Potent Antimicrobial Agentscombating Multidrugresistant Bacteria
ISSN: 2169-0022

Journal of Material Sciences & Engineering
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

8th International Conference and Exhibition on Materials Science and Engineering
May 29-31, 2017 Osaka, Japan

Ying Da Lai
National Cheng Kung University, Taiwan
Posters & Accepted Abstracts: J Material Sci Eng
DOI: 10.4172/2169-0022-C1-065
Abstract
Antimicrobial polypeptides has received significant attention because the challenge of serious multi-drug resistance of bacteria has been considered the most important issue in the world. We report the synthesis of star homopolypeptides and copolypeptides and their evaluation as antimicrobial agents. It is known thatdendritic or star-shaped structures facilitate antimicrobial polypeptides to efficiently interact with cell membranes and consequently enhance antimicrobial potency.Polypeptides with different arms were synthesized by Ring-Opening Polymerization (ROP) of N-Carboxy Anhydrides (NCAs) using initiators with corresponded number of functional group. GPC and NMR analyses confirmed the successful synthesis of these star polypeptides. Cationic, star polypeptides comprising poly(L-lysine) (PLL) were designed and synthesized as antimicrobial agents against Escherichia coli, Klebsiellapneumoniae(KP), Pseudomonas aeruginosaand Enterohemorrhagic Escherichia coli (EHEC) which are common pathogens found in nosocomial infection.It was found that the star polypeptides exhibited the enhancement of antimicrobial efficacy as compared to linear counterparts without hemolysis and significant cytotoxicity. Unlike the synthesis of antimicrobial, peptidebased dendrimers requiring complex and tedious reaction steps, the synthesis of these star polypeptides is simple and additional functionality can be incorporated by conjugation. Furthermore, antimicrobial polypeptides can overcome antibiotic resistance owing to their unique antibacterial process. Our present results demonstrated that these star polypeptides are promising antibacterial agentsfor the treatment of bacteria induced disease.
Biography

Ying-Da, Lai, 24 years old and he graduated from National Chung Cheng University and major in chemical engineering. Now, he is a master student in department of chemical engineering, National Cheng Kung University, and my thesis objective focuses on the synthesis of polypeptides which is applied on antibacterial agents. Good knowledge in the synthesis of polymer experienced in handling reactions under the glove box and the preparation of antibacterial experiment under Laminar flow and Biological Safety Cabinet. He participated in annual meeting of the Polymer Society, Taipei in 2017 and got the championship in the poster competition. With my great skill of polymer organic synthesis, He is confident that he can do well in the field of polymeric biomaterials. He is eager to be one of the scientists who can design promising antimicrobial agents to solve the tricky issue of the rising of antimicrobial resistance.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version