alexa Targeting Breast Cancer: A Metabolic Control Analysis Approach | 15935
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

3rd World Congress on Cancer Science & Therapy

Ettore Mutabito
Posters: J Cancer Sci Ther
DOI: 10.4172/1948-5956.S1.029
Abstract
In many diseases, such as cancer, cells show a specific metabolic shift from their normal physiological state. The differences between the normal and the altered metabolic phenotypes may be exploited to identify points of fragility characterising the disease, and hence to specifically target altered cells. The application of Metabolic Control Analysis (MCA) has been proposed as a possible way to identify such points of fragility at the metabolic level. Here we use an MCA approach to assess the suitability of different enzymes as molecular targets for drugs designed to attack breast cancer. We base our study on experimental data characterising the metabolic features of breast cancer, and make use, where possible, of actual kinetic equations in the attempt to provide the most realistic description of the system under study. Unknown metabolic and kinetic quantities are sampled randomly, providing us with a probabilistic assessment of the control profile of the system in the two metabolic phenotypes. The suitability of the different enzymes as molecular targets is subsequently assessed with respect to criteria of both high efficacy and low toxicity. The results obtained are in accordance with previous experimental work, highlighting the central role of certain enzymes such as GLT and G6PDH in controlling glycolysis and the pentose phosphate pathway respectively in some kinds of cancer.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7