alexa Targeting The DNA Damage Response Pathways In The Repair Of Acute Thermal And Ultraviolet Light Injury | OMICS International
ISSN: 2155-9554

Journal of Clinical & Experimental Dermatology Research
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

3rd International Conference on Clinical & Experimental Dermatology
April 15-17, 2013 Hilton Chicago/Northbrook, USA

Madalene C Y Heng
ScientificTracks Abstracts: J Clin Exp Dermatol Res
DOI: 10.4172/2155-9554.S1.008
Damage to the DNA resulting in double stranded breaks in the DNA (DSB) triggers the DNA damage response or DDR. This results in cell cycle arrest, associated with DNA Damage Response (DDR) pathways channeling repair enzymes to the damaged DNA histones. The presence of the DSBs is sensed by a multifunctional sensor complex (MRN). MRN complexes can bind to the exposed DNA ends directly and unwind the DNA ends in an ATP-dependent manner. This is important for nucleotide excision of the damaged segments of DNA, and later replication of the nucleotides during DNA repair. The DDR pathway involves recruitment of multiple proteins to the damaged DNA sites, including checkpoint proteins 1 and 2, and ubiquitin kinases. All activities within the cell are put on hold (cell cycle arrest), while nucleotide excision and repair pathways are initiated. When the cell is too badly damaged, apoptosis is induced but this only occurs after many attempts at repair, and apoptosis is only induced by replication stress when repair fails to occur. Cell cycle arrest is inhibitory to rapid healing of tissues. Moreover, the intrinsic repair processes are slow and laborious, and do not return the tissues to pre-injury levels. When large segments of the DNA are damaged, or if the damage involves both strands of the DNA, replication errors occur, producing a potentially premalignant cell. Curcumin is a phytochemical with anti-inflammatory, anti-photodamage and anti-carcinogenic properties. Curcumin induces apoptosis through inhibition of DDR pathways, with rescue of the damaged cells from cell cycle arrest. In this paper, we describe curcumin signaling targets in the DDR pathways as a basis for the rapid repair with no residual scarring in acute injury such as burns and sun-burn.

Madalene C Y Heng MD, FRACP, FACD, FAAD is Clinical Professor of Medicine/Dermatology UCLA School of Medicine. She was Chief, Division of Dermatology at the UCLA San Fernando Valley Program from 1979 to 2003. Dr Heng is a reviewer of multiple journals including the Journal of the American Academy of Dermatology, International Journal of Dermatology, British Journal of Dermatology, Lancet (London) and Molecular Pharmaceutics. With more than 130 publications including 76 publications in peer-reviewed journals on topics such as phosphorylase kinase activity in psoriasis and photodamaged skin, she is able to link treatment of disease to their pathophysiology and she is the developer of curcumin gel.

image PDF   |   image HTML

Relevant Topics

OMICS International Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
OMICS International Conferences 2016-17
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version