Journal of Stem Cell Research & Therapy

Teratogens against cancer

3^rd International Conference and Exhibition on Cell & Gene Therapy

October 27-29, 2014 Embassy Suites Las Vegas, USA

Vladimir Pak

Scientific Tracks Abstracts: J Stem Cell Res Ther

Abstract:

Small molecule teratogens can damage embryo cells but they are tolerable by adult mother?s cells. It is assumed that several teratogens taken with food, medicines or air can bind alpha-fetoprotein (AFP) instead of vital nutrition omega-3 docosahexaenoic acid (DHA). Like AFP-DHA, AFP-teratogen non-covalent complex can cross placenta and can be internalized by embryo cells through cell-surface AFP receptor. Majority of cancer cells, unlike normal adult cells re-express AFP receptor and can be damaged by AFP-teratogen complex due to the same delivery mechanism avoiding side effects. AFP-drug noncovalent complexes have shown promising results in cancer patients.

Biography :

Vladimir Pak has a PhD in Molecular Biology from the Institute of Bioorganic Chemistry, Moscow with over 30 years of Post doctoral experience in Virology, Biotechnology and Oncology. He is author of 7 patents related to API research and medicines manufacturing that excelled in quality to similar drugs on the Russian pharmaceutical market or replaced foreign drugs. He invented anti-cancer IV and oral medicines based on alpha-fetoprotein (AFP) as a tumor targeted carrier for apoptosis inducers.