This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
The targeting of drugs to specific cellular compartments is an emerging objective in animal health. Recently, there has been
success in targeting drugs to the mitochondrial membrane. Mitochondria damage/dysfunction contributes to a wide range
of diseases including aging, diabetes, defective apoptosis in cancer and degenerative diseases. Mitochondria damage/dysfunction
also influences energy production, energy partitioning in cells/tissues and efficiency of energy use which potentially contributes
to obesity as well as loss of physical strength and endurance. Reducing mitochondrial ROS generation induced by environmental
factors (i.e., diet) will allow more optimal activities of aconitase, ANT1, and beta oxidation, increase/maintain ATP supply, and
reduce diversion of calories to fat synthesis/accretion. While a number of peptide-based drug candidates have been reported,
a small number of lipophilic triphenyl phosphonium salt-based drug candidates have also been reported. While most of the
published studies are related to human health, applications to animal health are beginning to emerge. Vitamin E, BHT (di-tert-
butyl hydroxy toluene) and TBHQ (tert-butyl hydroquinone) are antioxidants used widely in the animal health industry. As part
of a study to enhance their effectiveness, we report the preparation of tethered analogs of Vitamin E, BHT, and TBHQ plus some
preliminary animal studies.
George A. Kraus received his B.S. from the University of Rochester in 1972 his Ph.D. from Columbia University in 1976. He is presently a University
Professor of Chemistry at Iowa State University. He has published more than 290 papers in peer-reviewed journals and is co-editor of the RSC
Green Chemistry book series.
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals