Medicinal & Aromatic Plants
Open Access

The ameliorating effects of Eclipta prostrata L. and its active compound, Eclalbasaponin II, against memory impairment

3^rd Global Summit on Herbals & Traditional Medicine

October 18-20, 2017 Osaka, Japan

Bokyung Koo, Won Yong Jung, Yulan Liao, Jiabao Zhang, Yubeen Kwon, Hojung Bae and Jong Hoon Ryu

Kyung Hee University, Republic of Korea
Kyung Hee University Medical Center, Republic of Korea

Posters & Accepted Abstracts: Med Aromat Plants

Abstract :

Eclipta prostrata L. (Asteraceae) has been used as whole body nourishment and nervine tonic in traditional herbal medicine. In the present study, we investigated the effect of E. prostrata on cognitive function. A single administration of E. prostrata ameliorated scopolamine- induced memory impairment in the passive avoidance, the Y-maze and the Morris water maze tasks. Moreover, hippocampal long-term potentiation and Western blot analyses were also employed to confirm the effects of E. prostrata on the levels of memory-related synaptic plasticity and biochemical parameters. Next, we conducted to isolate active compound from the ethanolic extract of E. prostrata by activity-guided fractionation method and found the Eclalbasaponin II, an oleanane-type triterpenoid saponin. We also conducted such behavior tasks to confirm the effect of Eclalbasaponin II on cognitive function. Similar to the extract of E. prostrata, Eclalbasaponin II (10 or 20 mg/kg, p.o.) significantly ameliorated the cognitive dysfunction induced by scopolamine in the above behavioral studies. Western blot analysis revealed Eclalbasaponin II increased the phosphorylation levels of Akt and GSK-3�?² in the hippocampus. These results suggest that E. prostrata and Eclalbasaponin II would be useful agents against cognitive dysfunction observed in the neurodegenerative disease such as Alzheimerâ�?�?s disease.

Biography :

Bokyung Koo is currently working at the Department of Life and Nanopharmaceutical Sciences at Kyung Hee University Republic of Korea.