alexa The Anticancer Mechanisms Of Docosahexaenoic Acid (DHA) And Eicosapentaenoic Acid (EPA) On Human Hepatocarcinoma: A Protoemic Approach
ISSN: 2161-0509

Journal of Nutritional Disorders & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

JOINT EVENT: 13th International Congress on Advances in Natural Medicines Nutraceuticals & Neurocognition & 14th International Conference on Clinical Nutrition
July 27-29, 2017 Rome, Italy

Jennifer Man-Fan Wan and Wing-Yan Jor
The University of Hong Kong, China
Posters & Accepted Abstracts: J Nutr Disorders Ther
DOI: 10.4172/2161-0509-C1-007
Abstract
Omega-3 fatty acids have been linked to cancers prevention. However it is not clear whether there are different anticancer mechanisms between the omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). The present study adpoted a protomic approach in order to identify specific biomarkers to define the signaling pathways that are unqiue to both DHA and EPA. By using the non-metastatic human epatocarcinoma cell line PLC/PRF/5, we have profiled the proteins espression of the PLC/PRF/5 cells after 72 hours treatment of DHA (200 μL) and EPA (200 μL) by the two dimensional gel electrophoresis (2D-PAGE). Differential expressed proteins were identified by the matrix-assiated laser desorption/ionization time of fight mass spectrometry (MALSI-TOF/TOF). Our results shows that both DHA and EPA inhibited cancer growth and induced apoptosis. DHA posed a stronger cytotoxic effect than EPA. Differentially expressed proteins in the signalling pathways, cell proliferation, tumor metastasis and apoptosis were found between EPA and DHA treatment. DHA suppressed calumenin and annexin A2, which are protins affecting tumor metastatic stability and EPA down-regulated. The heterogeneous nuclear ribonucleoprotein K (hnRNPK) and ubiquinol-cytochrome C reductase core protein 1 (UQCRC1) play a key role in the coordination of transcriptional responses to DNA damage and in mitochondria-to-nucleus retrograde reponse, respectively. The present study provides signature proteins associated with the anticancer mechanisms of DHA and EPA, and indicating some functional differencs betwen the two different types of omega-3 fatty acids in the prevention of human liver cancer.
Biography

Jennifer Man-Fan Wan has completed her PhD from Southampton University and Postdoctoral studies from Harvard Medical School, Boston, USA. She is an Assoicate Professor at the School of Biological Sciences, the University of Hong Kong. She has published more than 100 papers in reputed journals and has been serving as an Editorial Board Member of Nature Partner of Science of Food.

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords