Cerebral palsy (CP) is related to many defi
cits such as mental retardation, epilepsy, physical
deformities and the worldwide incidence being 2 to 2.5 per 1000 live births. Th
e exact etiology
of CP is poorly understood e.g. Hypoxia at the time of birth, genetic, antenatal infections, and
metabolic or traumatic insults. CP was considered as a non-curable, non-reparative disorder
but Stem cell therapy has a great potential for treatment of disorder like CP. Th
of this article is to report the use of autologous bone marrow stem cells (ABMSC?s)for CP
patients and to check the safety and effi
cacy. We transplanted 129.6X10
er enrichment. Th
e second dose of ABMSC?s (132.8X10
)was given seven days
rst transplant. Th
e grading of the patient was done with the help of Gross Motor Function
cation System and MACS. CNS examination showed good gross motor movements,
power noted in both UL and LL was grade IV. Bowel and bladder control has been achieved.
Notable improvement in speech was also noted. Cognitive level social know how was improved.
Pre and Post therapy analysis using Colour SPECT showed marked increase in perfusion
levels.In conclusion, autologous stem cell transplantation showed signifi
cant improvement in
Patient?s motor function and the method was found to be safe and reasonable.
Meghnad G Joshi, did Ph.D. from department of Zoology, Shivaji University, Kolhapur, India in 2006. He Joined
Karolinska Institute, Sweden as Postdoctoral fellow in 2007-2008 and worked for Sahlgrenska University
Hospital, Department of transplantation surgery, G?teborg, Sweden from 2008-2010. In 2009, he was awarded
with TTS New Key Opinion leader, Sweden. He has been appointed as a visiting Assistant professor by Kansas
medical Center, USA since 2010 till 2012. He has published more than 18 papers. Since 2011, he has joined
India?s leading stem cell therapy company, StemOne Biologicals Pvt. Ltd., Pune as the Lab director.
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