alexa The Balance Of Cellular And Humoral Immunity Determines The Level Of Protection Offered By An HIV Vaccine In Macaque Models Of HIV Infection
ISSN 2155-6113

Journal of AIDS & Clinical Research
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

2nd International Conference on HIV/AIDS, STDs, & STIs
October 27-29, 2014 Embassy Suites Las Vegas, USA

Timothy Fouts
Accepted Abstracts: J AIDS Clin Res
DOI: 10.4172/2155-6113.S1.009
Abstract
A guiding principle for HIV vaccine design has been that cellular and humoral immunity work together to provide the strongest degree of efficacy. However, three efficacy trials of Ad5-vectored HIV vaccines showed no protection. Transmission was increased in two of the trials, suggesting that this vaccine strategy elicited CD4+ T cell responses that provide more targets for infection, attenuating protection or increasing transmission. The degree to which this problem extends to other HIV vaccine candidates is not known. Here, we show that a gp120-CD4 chimeric subunit protein vaccine (full-length single chain (FLSC)) elicits heterologous protection against SHIV or SIV acquisition in three independent rhesus macaque repeated low-dose rectal challenge studies with SHIV162P3 or SIVmac251. Protection against acquisition was observed with multiple formulations and challenges. In each study, protection correlated with antibody dependent cellular cytotoxicity (ADCC) specific for CD4- induced epitopes (CD4i) provided that the concurrent anti-vaccine T cell responses were minimal. Protection was lost in instances where T cell responses were high or when the requisite antibody titers had declined. Our studies strongly suggest that balance between a protective antibody response and antigen-specific T cell activation is the critical element to vaccinemediated protection against HIV. Achieving and sustaining such a balance, while enhancing antibody durability, is the major challenge for HIV vaccine development, regardless of the immunogen or vaccine formulation.
Biography
Timothy Fouts is one of the founders and principle scientists at Profectus Biosciences. He directs a team of scientists in the discovery and preclinical development of vaccines, small molecule and antibody based antiviral therapies and microbicides that are within the Profectus research portfolio, in particular HIV and certain biothreat viruses. He has more than 32 scientific publications that have appeared in peer-reviewed journals and book chapters. He received his PhD in Immunology from the University of Maryland, Baltimore and did a postdoctoral fellowship at the Aaron Diamond AIDS Research Center at Rockerfeller University in NYC.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords