alexa The Complex Role Of Notch3 In The Kidney: Modulator Of Renal Hemodynamics During Development And Initiator Of CKD In Adulthood | 17503
ISSN: 2161-0959

Journal of Nephrology & Therapeutics
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

3rd International Conference on Nephrology & Therapeutics
June 26-27, 2014 Valencia Conference Centre, Valencia, Spain

Jean Claude Dussaule
ScientificTracks Abstracts: J Nephrol Ther
DOI: 10.4172/2161-0959.S1.013
Abstract
T he Notch3 receptor is normally expressed in vascular smooth muscle cells and participates in the development and maturation of vessels. Mutations of Notch3 in humans are associated with defective regulation of cerebral blood flow. The role of Notch3 in the regulation of renal hemodynamics was investigated using mice lacking expression of the Notch3 gene (Notch3-/-). The renal vascular resistance of Notch3-/- varied little after exogenous administration of vasoconstrictor or vasodilator agents. Renal resistance microvessels of Notch3-/- showed a deficient contractile response to vasoconstrictors due to a lower entry of extracellular calcium. This abnormal response was attributed to a developmental deficiency of the maturation of VSMC leading to structural heterogeneity in the thickness of the renal vascular wall and the dysfunction of calcium entry channels. In separate studies we found that a de novo activation of expression of Notch3 occurred in the renal epithelium following aggression (UUO and anti-GBM models of nephropathy). This de novo activation initiated phenotype changes making epithelial cells to acquire a pro-inflammatory, pro-migratory phenotype. Notch3-/- or wild type mice treated with antisense oligodeoxynucleotides targeting Notch3 were protected as they exhibited less proteinuria, uremia and inflammatory infiltration. These results show an important and complex role for Notch3 in renal physiopathology. Activation of Notch3 during development contributes to the maturity of resistance vessels and is necessary for the adaptive response of the renal vasculature to vasoactive systems. In contrast, neo-activation of Notch3 in adulthood is detrimental as initiates and contributes to cellular events associated to loss of renal function
Biography
Jean-Claude Dussaule (MD- PhD) is currently Professor of Physiology, University UPMC (Paris VI) and Chief of Division of Physiology, at St-Antoine Hospital, Director of the Medical Pole ?Sp?cialit?s M?dicales? of ?H?pitaux de l?Est Parisien? (Paris, France). He is a member of the Research Unit: UMR702 Inserm-UPMC, and has published more than 110 papers referenced in PubMed. His expertise regarding experimental research is in the fields of renal and vascular endocrinology, renal fibrosis and hemodynamics and hypertension.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version