Reach Us +1-504-608-2390
The Correlations Of Activins And Follistatin With Viral Load, Liver Damage, Interleukin-6 And Tumour Necrosis Factor-α In Treatment Naive Patients With Chronic Hepatitis C Genotype 1 And 4: A Casecontrol Study | 19602
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Recommended Conferences

7th International Congress on Infectious Diseases

Berlin, Germany

4th International Conference on Mass Spectrometry

Milan, Italy
Share This Page

The correlations of activins and follistatin with viral load, liver damage, interleukin-6 and tumour necrosis factor-α in treatment naive patients with chronic hepatitis C genotype 1 and 4: A casecontrol study

3rd International Conference and Exhibition on Clinical & Cellular Immunology

Ahmed Mohammed Ashshi, Bassem Refaat, Adel Galal El-Shemi and Adnan AlZanbagi

ScientificTracks Abstracts: J Clin Cell Immunol

DOI: 10.4172/2155-9899.S1.017

Background: Activins and follistatin are involved in the regulation of immune system and their importance in liver diseases has recently emerged Objectives: To measure the effect(s) of chronic hepatitis C (CHC) genotype 1 and 4 on the serum concentrations of activin-A, activin-B and follistatin, and to determine their correlations with viral load, liver damage, interleukin-6 (IL-6) and tumour necrosis factor (TNF)-α. Methods: Serum samples were collected from 20 male and 20 female treatment naive CHC genotype 1 and 4 Saudi patients (10 males and 10 females for each genotype), to measure activin-A, activin-B and follistatin by ELISA and the results were compared with 40 gender and age matched healthy participants. Additionally, the serum levels of the candidate proteins were correlated with IL-6, TNF-α, viral load and AST platelet ratio index (APRI). Results: SerumIL-6, TNF-α,activin-A and activin-B were significantly increased, whereas serum follistatin was significantly decreased, in both genders of CHC patients compared to control subjects.In both viral genotypes, activin-A was strongly and positively correlated with the viral load, APRI, IL-6 and TNF-α, and negatively with albumin (P<0.01). Activin-B showed similar correlations to activin-A but only in CHC genotype 1 patients and it was weaker than activin-A. No correlation was detected for follistatin. Conclusion: CHC genotype 1 and 4 significantly altered serum activinsand follistatin, and the dysregulation of activins/ follistatin axis could be associated with host immune response, viral replication and liver injury. More studies are required to elucidate the role(s) and clinical value of activins and follistatin in CHC.
Ahmed Mohammed Ashshi has completed his PhD(1999) Doctor of Philosophy in Medical and Molecular Virology,Faculty of Medicine, University of Manchester, United Kingdom(UK). AIBMS:(2001) Professional qualification in Medical Laboratory Sciences, Associate, Institute of Biomedical Sciences, United Kingdom (UK). Dean, Faculty of Applied Medical Sciences, Umm Al Qura University, Makkah Asociate Professor of Medical and Molocular Virology, Faculty of Applied Medical Sciences, Umm Al Qura University, Makkah, Kingdom of Saudi Arabia Chairman, Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al Qura University, Makkah, Kingdom ofSaudi Arabia.