alexa The Determinants Of Deleterious Effects Of Diabetes On Myocardium
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
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16th World Cardiology Congress
December 08-10, 2016 Dubai, UAE

Hany A AbdelWahab and Mohammad Gouda
Zagazig University Hospital, Egypt
Posters & Accepted Abstracts: J Clin Exp Cardiolog
DOI: 10.4172/2155-9880.C1.063
Abstract
Aim: Early discovery of diabetic heart disease is a dignified mission. Classic echocardiographic method is not sensitive to detect subclinical early LV systolic dysfunction. Early deleterious effects of DM on LV systolic function appeared longitudinally by speckle tracking. We aimed to uncover the determinants of deleterious effects of DM on the myocardium using echocardiographic indices, considering the duration of DM as well as the state of DM control. Methods: 52 diabetic patients were enrolled in two groups (group I; uncontrolled DM with HbA1c≥6.5% and group II; controlled DM with HbA1c<6.5% inside each group); we divided them according to the duration of DM into >5 years or <5 years DM. Results: Global longitudinal strain (GLS); it was impaired more in group I more than group II as there was a highly significant difference between both groups; -15.52.8% in-group I while it was -19.062.35% in-group II (t=-4.78, p=0.000). When we compared the GLS according to chronicity of DM; GLS was also impaired more with DM chronicity as there was significant difference between those with DM<5 years duration (-19.32.27%) and those with DM>5 years (-15.72.8%). (t=8.9, p=0.05). Conclusion: The duration of DM is strongly correlated with reduction of GLS and elevation of LV filling pressure. Poor glycemic control leads to reduction in GLS which is associated with preclinical LV dysfunction and elevated LV filling pressure.
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