alexa The Differences Between Mean Level Of Liver Enzymes And Platelet In Early Onset And Late Onset Preeclampsia At Dr. M Djamil Padang Hospital | 62350
ISSN: 2161-038X

Reproductive System & Sexual Disorders: Current Research
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2nd International Conference on Reproductive Health

Ismi Mulya Afti
Andalas University, Indonesia
Posters & Accepted Abstracts: Reprod Syst Sex Disord
DOI: 10.4172/2161-038X.C1.003
Abstract
Introduction & Aim: Pre-eclampsia is a leading cause of pregnancy-related morbidity and mortality maternal and neonatal in the world. The distinction based on clinical onset is made by early onset and late onset pre-eclampsia. Early onset and late onset pre-eclampsia has cause different etiology and pathophysiology. The theory of endothelial dysfunction in pre-eclampsia may explain the occurrence of hypertension that will reduce blood flow to the liver causing damage to liver cells and microangiopathic hemolysis characterized by elevated levels of the liver enzymes such as serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), and lactate dehydrogenase (LDH). In addition, endothelial dysfunction also causes activation and aggregation of platelets and the resulting decrease platelets in the bloodstream. This study aimed to determine the different liver enzymes level and trombosit between early onset and late onset preeclampsia. Method: This is an analytic study by taking secondary data from medical record of 110 pregnant women with preeclampsia in Dr. M Djamil Hospital. The sampling method is simple random sampling. Statistical analysis was done by SPSS program 16th version. Independent t- test undergo the mean difference. Results: The analysis showed SGOT and SGPT where p-value >0.05. This means that there are no significant statistic relationship between early onset and late onset pre-eclampsia with SGOT with p=0.455, SGPT with p=0.357. The analysis showed LDH and trombosit where p-value<0.05. This means that there is significant statistic relationship between early onset and late onset preeclampsia with LDH with p=0.003 and platelet with p<0.001. Conclusion: This study concludes that the mean level of LDH is significantly higher and the mean level of platelet is significantly lower in early onset pre-eclampsia. The mean levels of SGOT, SGPT are also higher in early onset preeclampsia.
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