alexa The Effect Of Δ9-Tetrahydrocannabinol On Memory Formation In Mice
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

Joint Conference 12th International Conference on Neurology and Neurophysiology & 2nd International Conference and Exhibition on Dual Diagnosis
May 18-20, 2017 Munich, Germany

Mina Mohammadkhani
Tehran University, Iran
Posters & Accepted Abstracts: J Neurol Neurophysiol
DOI: 10.4172/2155-9562-C1-050
Abstract
Memory disability is one of the well -known effects of cannabis on human behavior. Cannabis and its constituent cannabinoids are known to impair several aspects of cognitive function, with the most robust effect on short term, episodic and working memory in human. There is growing evidence of role of microtubule dynamic in memory formation and learning .dynamic microtubules are shown to be involved in dendritic spine changes and synaptic plasticity. Numerous studies shows that microtubules play important role in neuronal cells like axonal transportation and cell polarity .In order to investigate the effect of THC on memory formation we treated the mice with Δ⁹-tetrahydrocannabinol (THC) the most important ingredient of cannabis, then we studied the behavior of treated animals via T-maze test. To measure the effect of injection on microtubule of brain in closer condition to biological condition of brain, we used polymerization assay for brain extraction soup. We also found the alternation of microtubule polymerization in present of different concentration of THC and through turbidity spectroscopy and fluorescence spectrometry assay. THC also causes changing morphology of astrocyte cells. According to our results, THC impaired memory formation in treated animals and they had poor preformation which is related to microtubule kinetics.
Biography

Mina Mohammadkhani is graduated Biochemistry master student from Tehran University. Her passion for brain function and its mechanism made her doing her master thesis in molecular neuroscience lab in Institute of Biochemistry and Biophysics (IBB) and she was involved in investigation on memory formation . She works on the effect of Tetrahydrocannabinol(THC) (the most important psychotic ingredient of cannabis )on memory formation and brain function in mice through behavioral test , in vitro test on Microtubule and morphological study on astrocyte cell line.She is working as teacher’s assistant in neuroscience lab of IBB and cooperating in projects.(from Feb2016 )

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords