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|Mohd Alaraj, Ashfaque Hossain, Bahaa Al-Trad and Nasim Alaraj|
|University of Hail, Saudi Arabia
Ras Al Khaimah Medical and Health Sciences University, Ras Al Khaimah, UAE
Yarmouk University, Jordan.
Faculty of Medicine, Peoples’ Friendship University of Russia, Russia
|Posters & Accepted Abstracts: Pharmaceut Reg Affairs|
|Statement of the Problem: Inefficiency of hemodialysis (HD) is a major cause of the increased rate of morbidity and mortality observed in patients with end stage renal disease (ESRD). The recommended techniques to optimize HD achievement are still not fully successful. This may, at least in part, relate to inadequate understanding of the factors affecting the HD process, including drugs taking by these patients. Previously, we demonstrated that hemodialysis efficiency, particularly in patients with less than 50 years of age may be improved by decreasing the serum uric levels. In the current study, we assessed the potential relationship between ranitidine intake and hemodialysis efficiency among ESRD patients in Hail, Saudi Arabia. Methodology: A total of 275 hemodialysis patients (122 males and 153 females) were enrolled in this retrospective study. The range was 25 to 83 years with median age of 51 years. Blood sampling was collected pre- and post-HD to calculate the HD efficiency indices, particularly Kt/V, creatinine reduction ratio, uric acid ratio, and urea reduction ratio. Results: We found that the proportion of female patients with ESRD was significantly higher (60%; p<0.05), than the males in the patient group examined. Among hemodialysis patients, the incidence of hypertension was 86 % (p<0.05). There was a positive association between ranitidine supplementations and HD efficiency. A significant increase in Kt/V (p=0.03) ratio was detected in patient taken ranitidine. Also, significant increase in creatinine (p=0.008), uric acid (p=0.008), and urea (p =0.029) reductions were observed. Conclusions: Taken together, the results of this study indicate that the hemodialysis efficiency in HD subjects may be significantly improved by supplementation with ranitidine.|
Dr Alaraj (Associate Professor) was educated at Warsaw University, Poland and received a MS in Chemistry and Drug Technology in 1987. He obtained his PhD in 1995 from the College of Pharmacy, Medical University of Warsaw, Poland, having worked on the effects of polypeptide on the activity of some antiepileptic drugs. Dr Alaraj moved to “Mossakowski Medical Research Centre”, Polish Academy of Sciences where he begun research in calcium signaling and role of glucose on neurodegeneration. Since joining the Medical Faculty-University of Hail (2008), Dr Alaraj has been mainly involved in evaluating the hemodialysis efficiency and implication of uric acid in kidney impairment and other aspects of kidney diseases- among end stage renal disease (ESRD) patients. Recently he has identified that serum uric acid negatively affect the efficacy of HD. He is currently involved in identifying the relationship between drugs used and HD efficacy among ESRD patients.
Email: [email protected]
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