alexa The Effectiveness Of A Cucumis Sativus Extract (Imunopure Gherkin®) In The Management Of Osteoarthritis | 62765
ISSN 2472-1042

Pharmacoeconomics: Open Access
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

11th World Congress on Pharmaceutical Sciences and Innovations in Pharma Industry
February 27-28, 2017 Amsterdam, Netherlands

Boris G. Kingue Azantsa, Robert Nash, Hazel Sharp and Velmurugan Shanmugham
University of Yaoundé, Cameroon
PhytoQuest Limited, Plas Gogerddan, Aberystwyth, Ceredigion SY23 3EB, UK
PhytoQuest Limited, Plas Gogerddan, Aberystwyth, Ceredigion SY23 3EB, UK
Samrat Layout, Arekere, Bannerghatta Road, Bangalore 560076, Karnataka, India
ScientificTracks Abstracts: Pharmacoeconomics
DOI: 10.4172/2472-1042.C1.002
Abstract
Statement of the Problem: The global prevalence of osteoarthritis (OA) is escalating worldwide primarily because of the aging of populations and the rising prevalence of obesity. This study evaluated the ability of IminoPure Gherkin® (IPG®), a Cucumis sativus extract, to improve knee symptoms in OA. Methodology: A six-month (180 days) randomized, double-blind study was conducted with two groups of patients diagnosed with primary OA of the knee to compare the effects of IPG® with that of a combination of glucosamine hydrochloride and chondroitin sulphate (GC). One hundred twenty-two (122) OA patients aged 40-75 years with a body-mass index (BMI) of 18-30 kg/m2 were evaluated. The patients received either 10 mg of IPG® or GC twice daily for 180 days. Pain, stiffness and physical function were assessed in each patient using standard tools (visual analog scale (VAS), Lequesne's Functional Index (LFI), WOMAC at baseline (Day 0) and at Days 7, 30, 60, 90, 120, 150 and 180. Findings: The results were expressed as relative scores in percentages. The GC and IPG® treatments significantly (p<0.05) and gradually reduced the WOMAC, VAS, and LFI scores by Day 30 from the baseline value. The GK treatment significantly (p<0.05) reduced the WOMAC score by 22.44% at Day 30 and by 70.29% at Day 180. The daily reductions with IPG® were significantly (p<0.05) higher than that in the GC groups. From magnitude of the reductions, the IPG® treatment at Day 30 had reduced the WOMAC score by 6 ± 0.18% more than the GC treatment and further reduced it by 28.50 ± 0.14 and 39 ± 0.05% at Day 150 and Day 180, respectively. Additionally, the IPG® treatment at Day 30 reduced the average VAS scale by 8.6% and 20.77% at Day 180. At Day 30, the IPG® treatment reduced the average LFI Score by 12.29% and 18.90% at Day 150 and at Day 180, respectively. No adverse events (AEs) were recorded. Conclusion & Significance: Our results indicate the efficacy and potential use of IPG®, as an anti-OA therapy. It significantly (p<0.05) reduces the WOMAC, VAS, and LFI scores in patients suffering from OA, bringing about an improvement in knee pain, stiffness, and physical function.
Biography

Boris K G Azantsa has expertise in research on Metabolic Syndrome including Diabetes, Obesity Dyslipidemia and Hypertension. His research interests focuses on epidemiology and drug discovery from local herbal medicine. His research aimed at improving the health and wellbeing of patients and to valorize medicinal plants, herbs, spices traditionally used in Cameroon and Africa to treat a number of diseases.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version