alexa The Effects Of Sugar Cane Policosanol On The LDL, HDL, Triglyceride And Total Cholesterol Levels Of Dyslipidemic Patients: A Meta-analysis
ISSN: 2155-9627

Journal of Clinical Research & Bioethics
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

3rd International Conference on Advanced Clinical Research and Clinical Trials
September 20-21, 2017 Dublin, Ireland

Diana-Lynn S Que
St. Luke’s College of Medicine, Philippines
Posters & Accepted Abstracts: J Clin Res Bioeth
DOI: 10.4172/2155-9627-C1-003
Abstract
Policosanol, a plant-wax extract composed of a mixture of eight high molecular mass aliphatic alcohols, is commonly used as a supplement to help lower cholesterol levels in patients with dyslipidemia. Despite its widespread use, studies showed conflicting conclusions regarding its efficacy. This study aims to consolidate the available research findings regarding the efficacy and benefits of policosanol and to compare the effects of policosanol versus placebo on the lipid profile of dyslipidemic patients. A literature search was done using PUBMED database using “Policosanol (MESH or free text) AND dyslipidemia (MESH or free text)” limited to human subjects, male and female, clinical trials, and randomized controlled trials. Three independent reviewers conducted validity assessment for each included studies. Review Manager was used to construct Forest and funnel plots for each outcome. Subgroup analysis was likewise done. This meta-analysis includes a total of 10 randomized controlled trials, double blinded, and placebo controlled studies. A total of 875 participants were given policosanol, irrespective of dosage and the duration of treatment while 878 received placebo treatment. Overall percent change in total cholesterol favored policosanol (-7.24[-11.99, -3.29]) with a significant difference (p=0.0003). A significant difference was likewise seen in LDL-C (p=0.001) also favoring policosanol (-8.67[-13.99. -3.34]), as well as in HDL-C (9.94 [3.32, 15.65], p=0.003). However, the studies were very much heterogeneous (p<0,00001, I2=100%). No significant difference (p=0.30) was seen in terms of triacylglycerides. On subgroup analysis using 10mg of policosanol versus placebo for 12 weeks, a significant difference (p<0.00001) was found favoring policosanol in terms of total cholesterol (-17.93 [- 19.85, - 16.00]), LDL-C (-22.08 [-25.91, -18.26]) and HDL-C (23.05 [20.28, 25.82]). In conclusion, policasanol was found to significantly improve the lipid profile parameters specifically total cholesterol, LDL-C, and HDL-C but not TAGs in dyslipidemic patients at dose of 10mg for 8 weeks. Side effects were very minimal; policosanol is generally safe and well tolerated.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords