Synaptonemal complex protein 3 (SCP3) is a marker for cell transformation, and
it has been shown that the overexpression of SCP3 in tumor cells could lead to activation of
is study explored expression of SCP3 and its relationship with the phosphorylated
AKT (p-AKT) in cervical neoplasias.
Five hundred seven cervical tumor samples and matched normal
epithelial samples were arrayed into tissue microarrays. Th
e status of SCP3 and p-AKT was
studied using immunohistochemical analysis. Staining results for each antibody were compared
with clinical and pathologic features, and the relationship between staining results was explored.
Expressions of SCP3 and p-AKT were signifi
cantly increased in cervical cancer
cases compared with normal epitheliums (P < 0.001, each). Increased SCP3 expression was
observed in patients with increasing tumor stage (P = 0.002) and tumor grade (P < 0.001). In
multivariate analysis, disease-free survival in cervical cancer patients was signifi
cantly shorter in
cases with overexpression of SCP3 (HR = 4.81 [1.37-16.95], P = 0.014), lymph node metastases
(HR = 3.07 [1.23-7.67], P = 0.016), and advanced tumor stage (HR = 2.74 [1.09-6.88], P =
0.032). SCP3+/p-AKT+ expression (P =0.034) and increased tumor stage (P = 0.006) showed
shorter overall survival by Kaplan-Meier analysis.
is study shows that SCP3 expression in addition to p-AKT predicts poor
prognosis in cervical cancer. Moreover, the correlation between expressions of SCP3 with
p-AKT indicates that SCP3 activation through the AKT pathway plays an important role in the
progression of cervical cancer.
cervical cancer; tissue microarray;
immunohistochemistry; SCP3; AKT pathway
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