alexa
Reach Us +1-217-403-9671
The Genome Solver Project: Facilitating Undergraduate Research Projects In Bioinformatics | 9013
ISSN: 0974-276X

Journal of Proteomics & Bioinformatics
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

The genome solver project: Facilitating undergraduate research projects in bioinformatics

3rd International Conference on Proteomics & Bioinformatics

Anne G. Rosenwald, Bradley A. Murray, Theodore Toth, Gaurav S. Arora, Janet Russell and Ramana Madupu

ScientificTracks Abstracts: J Proteomics Bioinform

DOI: 10.4172/0974-276X.S1.067

Abstract
The Human Microbiome Project is revolutionizing our understanding of the microorganisms that coexist in and on the human body, and the relationship between the microbiome and human health. The sequence information from thousands of bacteria and bacteriophages is available in public repositories. This vast data set represents an opportunity for undergraduates to engage in authentic bioinformatics research. We have developed the Genome Solver online community for faculty and students to share curriculum and research. As an illustration of the work that can be done, we show one project in which students found evidence for gene transfer between Chlamydia (Chlamydophila) pneumoniae isolates and Chlamydia phages. We found that two phage genes are found in a C. pneumoniae isolate which infects koalas, but only one of these, encoding a putative replication initiation protein (PRIP), is found in the isolates that infect humans. We further show by phylogenetic analyses that the PRIP proteins from the phages cluster together while the PRIP proteins from bacteria cluster together. These results are consistent with the hypothesis that phage genes were transferred into a C. pneumoniae ancestor that gave rise to the koala-infecting strain as well as the human-infecting strains, while the immediate ancestor of the human strains lost the second phage gene and retains only the PRIP gene. These observations suggest that the bacterial PRIP gene is retained because it serves an important, though unknown function. We are extending these results to examine transfer of PRIP genes between other phage and their bacterial hosts.
Biography
Leave Your Message 24x7
Top