alexa The Impact Of Histological Re-evaluation Of Tissue Engineered Startegies In Articular Cartilage Repair -Results Of Human Applications
ISSN: 2157-7552

Journal of Tissue Science & Engineering
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

3rd International Conference on Tissue Science & Regenerative Medicine
September 24-26, 2014 Valencia Convention Centre, Spain

Christoph Brochhausen
ScientificTracks Abstracts: J Tissue Sci Eng
DOI: 10.4172/2157-7552.S1.014
Abstract
S everal tissue engineering based strategies to treat articular cartilage defects ? such as autologous chondrocytes transplantation (ACT) or matrix assited autologous chondrocyte transplantation (MACT) - are already in clinical use. However, none of them provides optimal results with view to regeneration of hyaline cartilage. An innovative new strategy to treat articular cartilage lesions is the implantation of autologous chondrocytic spheroids. We present histological re-evaluations of second- look biopsies of MACT patients and for the first time such of autologous chondrocytic spheroid application. Biopsies were taken from 6 patients treated with Standardized synthesized MACT-constructs or autologous chondrocytic spheroids. The Second-look biopsies were taken between four and sixteen months after implantation during a second arthroscopy, which was indicated independent of the (ACT). Biopsies (n=2) were fixed in buffered formalin and prepared according to standard methods for conventional histological (HE, alcian-blue) and immunohistochemical (collagen II, aggrecan) examination followed by semiquantitative evaluation. Biopsies from MACT-constructs showed fibrous tissue without relevant collagen II or aggrecan expression. Biopsies from spheroid based autologous chondrocyte transplantation showed typical articular cartilage architecture with expression of collagen II and aggrecan. To our knowledge this study is the first histomorphological evaluation of scaffold-free spheroid based ACT in humans. The heterogeneous results of our re-evaluations demonstrated the need for a systematic biopsy-collection and their combination with clinical data to provide an evident evaluation of the used tissue engineering based strategies to treat cartilage defects. Furthermore, such analyses could give an innovative input in further developments of the guided tissue engineering of cartilage defects.
Biography
Christoph Brochhausen is Chief Consultant Pathologist and Head of Electron Microscopy at the Institute of Pathology at the University Medical Centre Mainz as well as Group Leader of the Cartilage Tissue Engineering Group at the REPAIR-lap. His research-work was awarded by national and international awards. He has published more than 80 papers in reputed journals and serving as an editorial board member of some reputed journals.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version