alexa The Influence Of IL-10 Gene Polymorphisms On The Susceptibility To Hepatitis B Virus Infection: A Meta-analysis
ISSN: 2155-9597

Journal of Bacteriology & Parasitology
Open Access

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5th International Congress on Bacteriology and Infectious Diseases
May 25-26, 2017 Chicago, USA

Bita Moudi, Zahra Heidari, Hamidreza Mahmoudzadeh Sagheb, Alireza Ansari Moghaddam and Mehrnoosh Moudi
Zahedan University of Medical Sciences, Iran
Islamic Azad University, Iran
Posters & Accepted Abstracts: J Bacteriol Parasitol
DOI: 10.4172/2155-9597-C1-029
Abstract
Interleukin 10 (IL-10) is a cytokine with anti-inflammatory functions. The results of the different studies vary in the roles of the IL-10 SNPs in the susceptibility to the hepatitis B virus infection. In particular, the -1082A/G, -819 C/T and -592 A/C polymorphisms have most often been implicated. We have performed a meta-analysis including 31 case-control studies to summarize the data on the association between IL-10 SNPs and susceptibility to HBV infection. All the relevant studies in NCBI PubMed, EMBASE, Medline and Web of Science were searched and poor qualified studies were excluded. Thirty one (31) studies were included. Data are presented as the odds ratio (OR) with a 95% confidence interval (CI). Investigation of heterogeneity among individual studies and the publication bias were also evaluated. This study revealed a significant association between the IL-10-89 C/T polymorphism and HBV infection susceptibility in the Asian population. Our results indicated that the presence of the IL-10 -819 C allele significantly increased the risk for persistent HBV infection. In our metaanalysis, sensitivity analysis showed that the combined result was not associated with the worldwide population. In contrast, the IL-10 -1082A/G and -592A/C polymorphisms were not associated with an increased susceptibility to HBV infection. Our meta-analysis supports the growing body of evidence that the presence of the IL-10-819 C/T SNP is associated with persistent HBV infection in Asians. In addition, IL-10-819 C/T polymorphism might be a risk factor for HBV in Asians but not in Europeans.
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