alexa The Interaction Between Iron And Nε-(carboxymethyl)lysine And Its Association With Non-alcoholic Fatty Liver Disease
ISSN: 2155-9600

Journal of Nutrition & Food Sciences
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

10th World Congress on Nutrition & Food Sciences
May 29-31, 2017 Osaka, Japan

Nindy Sabrina and Jung-Su Chang
Taipei Medical Universty, Taiwan
Posters & Accepted Abstracts: J Nutr Food Sci
DOI: 10.4172/2155-9600-C1-045
Abstract
Background: Dysregulated iron metabolism is a common disorder in non-alcoholic fatty liver disease (NAFLD). Recently, the advanced glycation end products (AGEs) and it’s receptors (RAGE) are also linked to the pathogenesis of NAFLD. The aim of this study was to investigate the interactive effects of iron-AGE axis on fatty liver severity. Methods: NAFLD was diagnosed based on abdominal ultrasonography. In total, 170 Taiwanese adults (33 controls and 137 NAFLD) were selected for analysis. Parameters for RBC, iron status, soluble CD163 (sCD163), cell free hemoglobin (Hb) and Nε-(carboxymethyl) lysine (CML) were evaluated. Results: Multivariate linear regression analysis confirmed that serum free Hb (Beta=-1.1(-1.4--0.74); p<0.0001) and soluble CD163 (Beta=0.053 (0.01-0.09); p<0.05) are independent predictors of serum CML. Interactive analysis showed that, compared to those with the lowest sCD163 (T1) and free Hb (T1), individuals with the highest free Hb tertile (T3) and the lowest sCD163 tertile (T1) had an negative predicting effect on serum CML (Beta= -93.136 (-185.1—1.177); p =0.047) and the inverse relationship changes with increasing tertile groups of sCD163 (Beta=-46.54 (-139.2-46.1) and 65.1 (-12.6-142.84) for T2 and T3, respective; p-trend=0.011). Categorical logistic regression analysis showed that, compared to individuals with the lowest serum free Hb and CML median (M1, Reference), individuals with the highest serum CML (M2) and free Hb (M2) had 6.86 times (95% CI: 1.85-125.4; p=0.004) times highest risk for NAFLD and the odds increased to 8.66 times (95%CI: 1.684- 44.48; p=0.01) after adjusting for age, gender and BMI. Conclusion: Our results raise the possibility that increased shedding of CD163 surface receptor may interfere with CD163+macrophage’s ability to recycle serum free Hb and increased free Hb level may lead to the endogenous formation of CML and liver injury.
Biography

Nindy Sabrina is a second year master student in the School of Nutrition and Health Sciences, Taipei Medical University, Taiwan. Nindy is originally from Malang, Indonesia. She received her undergraduate education at Brawijaya University, Indonesia, with a degree in Nutrition and Health. Currently, she is actively involved in Indonesia Student Association in Taiwan. Nindy is broadly interested in human nutrition research particularly obesity, iron, and advanced glycation end products. In her master research, she is seeking to understand the relationships between dietary intake, serum iron biomarkers and advanced glycation end products in Non- Alcoholic Fatty Liver Disease (NAFLD) patient in Taipei.

Email: [email protected]

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords