alexa The Obligatory Role Of Endogenous Retroviruses In Human Pregnancy: An Overview
ISSN: 1948-5964

Journal of Antivirals & Antiretrovirals
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

4th World Congress on Virology
October 06-08, 2014 Hilton San Antonio Airport, TX, USA

Neal S Rote
Keynote: J Antivir Antiretrovir
DOI: 10.4172/1948-5964.S1.019
Abstract
The genome of most vertebrates has been transformed over millions of years by in-heritable integration of infectious retroviruses leading to rapid evolutionary changes as the host accommodated and used advantageous retroviral proteins. Approximately 8% of the human genome is of apparent retroviral origin (endogenous retroviruses; ERV). Although most retroviral integration sites are completely or partially inactivated through gene modification, a small number of isolated ERV elements retain transcriptionally active open reading frames so that a variety of Gag, Pol, and Env proteins may be expressed. The placenta is one of few organs that express ERV proteins under physiologic conditions. Specialized cells of the human placenta (villous cytotrophoblast) differentiate into syncytiotrophoblast by exiting the cell cycle, intracellular fusion, and secretion of preg-nancy-related hormones (e.g., chorionic gonadotropin; hCG) concurrent with expression of more than 30 different ERV-encoded proteins and shedding of non-infectious virions from the basal surface of the syncytiotrophoblast. In 1998, we published the first physio-logical role for a placental ERV protein; expression of env of a single copy ERV (ERV3) induced the β subunit of hCG (β-hCG) and diminished cell division in a cAMP/PKA-dependent manner. Later, others described physiologic roles for two other ERV env ele-ments, HERV-W and HERV-FRD, which produce typical ERV Env proteins (syncytin-1, syncytin-2) that mediated the intertrophoblast fusion process. ERV3 Env, however, is highly atypical with a proposed primary sequence incompatible with an effective fusion protein; lacking a functional membrane spanning domain, a relatively hydrophilic fusion peptide, and an atypical immunosuppressive site. As shown recently, ERV3 env encodes a hormonal control site located in the N-terminal p25 truncated molecule from the SU re-gion; completely unique to retroviral env elements. The argument may be put forth that placentation, perhaps throughout all placentate animals, may have evolved through the capture and selective expression of retroviral elements, the physiological function of most of which remain unknown.
Biography
Neal S. Rote completed his Ph.D. at Temple University School of Medicine and postdoc-toral studies at Heidelberg University and UCLA School of Medicine. He is the William Weir, M.D. Professor of Reproductive Biology and Professor of Pathology at Case West-ern Reserve University School of Medicine and Academic Vice Chair and Director of Research in the Department of Obstetrics and Gynecology, University Hospitals Case Medical Center, Cleveland, OH. He has published more than 110 papers in reproductive biology and 75 chapters and books, been NIH-funded for 32 years, and served on many NIH review committees.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords