alexa The Pharmacodynamic Study And Safety Evaluation On Tuberculosis DNA Vaccines
ISSN: 2157-7560

Journal of Vaccines & Vaccination
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

3rd International Conference on Vaccines & Vaccination
July 29-31, 2013 Embassy Suites Las Vegas, NV, USA

Xueqiong Wu, Yan Liang and Zhongming Li
ScientificTracks Abstracts: J Vaccines Vaccin
DOI: 10.4172/2157-7560.S1.016
Abstract
T he situation of TB and MDR-TB was severe, especially in developing countries. It is mainly due to lacking of effective vaccine and the funding to support the treatment of MDR-TB with second line anti-TB drugs. It was proved that DNA vaccine could be a novel and potentially powerful agent to prevent and treat disease. We have constructed various TB DNA vaccines used plasmid pVAX1 as vector, for example, DNA vaccines expressing proliferating antigens, latency antigens, cytokines, chimeric DNA vaccine (Ag85A/ESAT6, Ag85A/Ag85B) and mixed DNA vaccines. ESAT6, Ag85A, Ag85B DNA mainly elicit Th1 type immune responses, and MPT64 DNA elicit both humoral and cellular immune responses. ESAT6, Ag85A and Ag85B DNAs had better protective efficacy than MPT64 DNA. IFN-g and IL-12 DNAs can enhance the protective efficacy of MPT64 DNA. Ag85A or Ag85A/Ag85B DNA alone or combined with RFP or PZA had better immunotherapeutic effects on drug-sensitive or MDR-TB mouse model, but Ag85A/ESAT6 DNA may cause the death of mice, which is mainly caused by hypersensitivity. The immune responses were enhanced in mice after vaccination intramuscularly with electroporation using Ag85A DNA. Electroporation improved the efficiency of gene expression and the immunogenicity of DNA, and can reduce 10 times amount of DNA. 1 mg TB DNA vaccines can elicit effectively immune responses in the primate animals. The cynomolgus monkey immunized by 0.2, 1, 5 mg Ag85A DNA did not find any adverse reaction. The therapeutic Ag85A DNA vaccine and the combination with anti-TB drugs are the promising and affordable strategies for the treatment of MDR-TB disease in developing countries.
Biography
Xueqiong Wu, M.D., Ph.D., The Director of Army Tuberculosis Prevention and Control Key Laboratory, The Vice Head of Institute of Tuberculosis Research, the 309 th Hospital of Chinese PLA, China. She does research on tuberculosis (TB) in the following directions: (1) new TB vaccines (2) the new, rapid diagnostic techniques of TB, for example, mycobacterial species identification, rapid detection of M. tuberculosis and its drug resistance, risk prediction of anti-TB drug-induced hepatotoxicity, rapid diagnosis of bacterium-negative TB, etc. (3) new Chinese herbal medicine.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

agriaquaculture@omicsonline.com

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

biochemjournals@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

chemistryjournals@omicsonline.com

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

clinicaljournals@omicsonline.com

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

engineeringjournals@omicsonline.com

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

nutritionjournals@omicsonline.com

1-702-714-7001Extn: 9042

General Science

Andrea Jason

generalscience@omicsonline.com

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

geneticsmolbio@omicsonline.com

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immunomicrobiol@omicsonline.com

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

nursinghealthcare@omicsonline.com

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

medicaljournals@omicsonline.com

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuropsychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

pharmajournals@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords