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orty-two albino male rats aged between 30 and 40 days (weighted 200 g to 250 g) were used in the present study. The left
sural nerves of 36 rats were subjected to crush injury at 1 to 6 weeks intervals using 6 animals at each interval. The right and
left sural nerves of the rest 6 rats were used as a control. After 2 weeks of the crush injury, the endoneurium showed channel-
like spaces that were lined by the fibroblast-like cells and collagen bundles. These channels contained degenerated myelin and
were connected with the perivascular and subperineurial spaces. Some of the flattened fibroblast-like cells were arranged in
several layers in the subperineurial and perivascular spaces, forming barrier-like cellular sheets localizing the endoneurial
edema in these spaces. Fibroblast-like cells also wrapped the regenerating nerve fibers by their branching cytoplasmic
processes. At the end of the third week, the flattened fibroblasts formed nearly continuous sheets in the subperineurial and
perivascular spaces. Macrophages were frequently noticed between these cellular barrier-like sheets and in the subperineurial
and perivascular spaces. It could be concluded that the endoneurial fibroblast-like cells form barrier-like cellular sheets that
localized the endoneurial edema in the subperineurial and perivascular spaces and create also the endoneurial channel-like
spaces containing degenerated myelin and endoneurial edema helping the resolution of such edema.
Wagih G Elbarrany has completed his PhD from Alexandria University and Postdoctoral studies from Charing-Cross Hospital Medical School (London University).
He is a Prof. of Anatomy and Embryology, Umm Al-Qurauniversity, Makkah, Saudi Arabia. He has published more than 20 papers in different national and
international journals and serving as an editorial board member of
Umm Al-Qura Medical Journal
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