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The environmental fate and potency of mutagenic compounds is of growing concern. This has necessitated the development
and application of rapid assays to screen large numbers of samples for their genotoxic and carcinogenic effects. Despite the
development of biosensors for genotoxicity assessment, these have not been calibrated against traditional microbial bioassays.
In this study, assays using the SOS-lux marked microbial biosensors E. coli K12C600 and E. coli DPD1718 were refined and
optimised to screen selected mutagenic chemicals. The response of the biosensors was compared to the mutagenic response of the
traditional Salmonella mutagenicity assay. For the chemicals tested (acridine, B[a]A, B[a]P, chrysene, MMC and sodium azide),
E. coli DPD1718 was consistently more sensitive than E. coli K12C600. The biosensors were of comparable sensitivity to the
Salmonella assay but were more rapid, reproducible and easier to measure. These data validate the adoption of optimised assays
making use of microbial biosensors for routine screening of test chemicals.
Hani Alhadrami is reading for the degree of doctor of philosophy in Microbiology and Biotechnology. He has recently passed his PhD viva with minor
corrections and he is expecting to be graduated in September 2013. The PhD is a sharing degree between the University of Aberdeen, United
Kingdom and the University of Dammam, Saudi Arabia. The tittle of the thesis is Development and Applications of Mutagenicity and Carcinogenicity
Bioassays for Human Health Risk Assessment. Hani was obtained his MSc in Environmental Microbiology (with Commendation) from the University
of Aberdeen, UK in 2008. The project title for the master degree was: Assessing the Potential of Flow Bioreactors to Minimise Human Health and
Environmental Impacts of Landfill Leachates Using Microbial Biosensors. Hani obtained his BSc (Honours) in Medical Technology, King Abdulaziz
University, Saudi Arabia. He worked as a co-supervisor for two master students during his PhD period, and taught undergraduate students at both the
University of Aberdeen and the University of Dammam. Hani?s research interest is development of biosensors for mutagenicity and carcinogenicity
assessment. Hani has published three scientific papers in peer-reviewed international journals as well as two book chapters in the applications of
biosensors for environmental monitoring.
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