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The Protective Effect Of Simvastatin Against UVB-induced Corneal Endothelial Cell Death | 86547
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
Open Access

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The protective effect of simvastatin against UVB-induced corneal endothelial cell death

Joint Event on 10th International Conference on Genomics and Molecular Biology & 6th International Conference on Integrative Biology

Yi Ru Ho and Chan Yen Kuo

Chan Bing Show Chwan Memorial Hospital, Taiwan Hsin Sheng Junior College of Medical Care and Management, Taiwan National Central University, Chungli, Taiwan

Posters & Accepted Abstracts: J Mol Genet Med

DOI: 10.4172/1747-0862-C2-028

Ultraviolet B (UVB) radiation is a risk factor for uveitis, and excessive UVB exposure causing corneal endothelium injury, including apoptosis, is a serious condition. Therefore, drugs that can inhibit apoptosis in corneal endothelial cells represent an effective strategy for treating uveitis. Simvastatin is widely used as a specific inhibitor of 3-hydroxy-3-methyl-glutaryl-CoA reductase, can reduce levels of low density lipoprotein (LDL) cholesterol, and exerts anti-inflammatory effects. However, the effect of simvastatin on uveitis remains unclear. Therefore, the aim of this study was to elucidate whether UVB promotes the initiation of apoptosis in corneal endothelial cells and subsequently contributes to uveitic injury reversible by simvastatin treatment. Our findings indicated that simvastatin alleviated UVB-induced corneal endothelial cell apoptosis via caspase-3 activity.

Yi-Ru Ho completed her Graduation from Department of Molecular Biology and Human Genetics, Tzu Chi Universit. Currently, she is a Research Assistant in Department of Medical Research Chang Bing Show Chwan Memorial Hospital. She is interested in “Primary cell culture of ADMSC, cell culture of neuron cell, MTT assay, DNA extraction, qPCR, Western blot, flow cytometry of cell cycle and cell marker, Luciferase assay, siRNA transfection, Enzyme-linked immunosorbent assay, intraperitoneal injection of mice”.
Email:[email protected]